{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:15:15Z","timestamp":1753888515009,"version":"3.41.2"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saude soc."],"abstract":"<jats:p>Resumo Hemocromatose heredit\u00e1ria (HH) \u00e9 a doen\u00e7a gen\u00e9tica mais comum em descendentes de europeus e sua epidemiologia em nosso pa\u00eds \u00e9 incerta. Considerando o cen\u00e1rio das pol\u00edticas p\u00fablicas em HH no mundo contempor\u00e2neo, este artigo prop\u00f5e uma reflex\u00e3o sobre o tema, com objetivo de fazer uma revis\u00e3o bibliogr\u00e1fica narrativa sobre a abordagem adotada para essa doen\u00e7a em pa\u00edses desenvolvidos e a n\u00edvel nacional. Al\u00e9m disso, discute sobre o custo-benef\u00edcio da incorpora\u00e7\u00e3o do \u00edndice de satura\u00e7\u00e3o da transferrina (ST) e ferritina s\u00e9rica (FS) no nosso sistema de sa\u00fade, com a finalidade de identificar a HH antes que surjam suas complica\u00e7\u00f5es, bem como seu rastreio em campanhas nacionais de preven\u00e7\u00e3o. O valor gasto para o screening da HH com dosagem de ST e FS pelo Sistema \u00danico de Sa\u00fade (SUS) \u00e9 muito menor do que os custos gerados quando o dano por excesso de ferro j\u00e1 est\u00e1 estabelecido. Nos casos suspeitos de HH, deveria ser viabilizada pelo SUS a pesquisa da muta\u00e7\u00e3o gen\u00e9tica para o gene HFE, que atualmente s\u00f3 est\u00e1 dispon\u00edvel de forma privada. Com essas medidas, modifica-se a hist\u00f3ria natural da doen\u00e7a, reduzindo a morbimortalidade dos portadores e custos ao sistema p\u00fablico de sa\u00fade.<\/jats:p>","DOI":"10.1590\/s0104-12902023210915pt","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T15:20:36Z","timestamp":1702653636000},"source":"Crossref","is-referenced-by-count":0,"title":["Cen\u00e1rio das pol\u00edticas p\u00fablicas para hemocromatose heredit\u00e1ria no Brasil"],"prefix":"10.1590","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-6234","authenticated-orcid":false,"given":"Cristiane da Silva Rodrigues de","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-0015","authenticated-orcid":false,"given":"Anna Laura Duro","family":"Barp","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3898-5873","authenticated-orcid":false,"given":"D\u00e9borah","family":"Glimm","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-2243","authenticated-orcid":false,"given":"Francisco Costa Beber","family":"Lemanski","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4954-2922","authenticated-orcid":false,"given":"Lara Beatriz Silva Gon\u00e7alves","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0243-8754","authenticated-orcid":false,"given":"Saulo Bueno de","family":"Azeredo","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7544-9425","authenticated-orcid":false,"given":"Adriano","family":"Pasqualotti","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo,  Brasil"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"17","key":"ref1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1056\/NEJMoa041534","article-title":"Hemochromatosis and Iron-Overload Screening in a Racially Diverse Population","volume":"352","author":"ADAMS P. 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