{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:23:43Z","timestamp":1773411823138,"version":"3.50.1"},"reference-count":76,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol\u00edmeros"],"abstract":"<jats:p>Micropart\u00edculas produzidas a partir de pol\u00edmeros sint\u00e9ticos t\u00eam sido amplamente utilizadas na \u00e1rea farmac\u00eautica para encapsula\u00e7\u00e3o de princ\u00edpios ativos. Essas micropart\u00edculas apresentam as vantagens de prote\u00e7\u00e3o do princ\u00edpio ativo, mucoades\u00e3o e gastrorresist\u00eancia, melhor biodisponibilidade e maior ades\u00e3o do paciente ao tratamento. Al\u00e9m disso, utiliza menores quantidade de princ\u00edpio ativo para obten\u00e7\u00e3o do efeito terap\u00eautico proporcionando diminui\u00e7\u00e3o dos efeitos adversos locais, sist\u00eamicos e menor toxidade. Os pol\u00edmeros sint\u00e9ticos empregados na produ\u00e7\u00e3o das micropart\u00edculas s\u00e3o classificados biodegrad\u00e1veis ou n\u00e3o biodegrad\u00e1veis, sendo os biodegrad\u00e1veis mais utilizados por n\u00e3o necessitam ser removidos cirurgicamente ap\u00f3s o t\u00e9rmino de sua a\u00e7\u00e3o. A produ\u00e7\u00e3o das micropart\u00edculas polim\u00e9ricas sint\u00e9ticas para encapsula\u00e7\u00e3o tanto de ativos hidrof\u00edlicos quanto hidrof\u00f3bicos pode ser emulsifica\u00e7\u00e3o por extra\u00e7\u00e3o e\/ou evapora\u00e7\u00e3o do solvente; coacerva\u00e7\u00e3o; m\u00e9todos mec\u00e2nicos e est\u00e3o revisados neste artigo evidenciando as vantagens, desvantagens e viabilidade de cada metodologia. A escolha da metodologia e do pol\u00edmero sint\u00e9tico a serem empregados na produ\u00e7\u00e3o desse sistema dependem da aplica\u00e7\u00e3o terap\u00eautica requerida, bem como a simplicidade, reprodutibilidade e factibilidade do aumento de escala da produ\u00e7\u00e3o.<\/jats:p>","DOI":"10.1590\/s0104-14282011005000060","type":"journal-article","created":{"date-parts":[[2011,10,29]],"date-time":"2011-10-29T05:16:09Z","timestamp":1319865369000},"page":"286-292","source":"Crossref","is-referenced-by-count":5,"title":["Pol\u00edmeros sint\u00e9ticos biodegrad\u00e1veis: mat\u00e9rias-primas e m\u00e9todos de produ\u00e7\u00e3o de micropart\u00edculas para uso em drug delivery e libera\u00e7\u00e3o controlada"],"prefix":"10.1590","volume":"21","author":[{"given":"Patr\u00edcia","family":"Severino","sequence":"first","affiliation":[{"name":"UNICAMP; UFP"}]},{"given":"Maria Helena A.","family":"Santana","sequence":"additional","affiliation":[{"name":"UNICAMP"}]},{"given":"Samantha C.","family":"Pinho","sequence":"additional","affiliation":[{"name":"USP"}]},{"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"UFP; UTAD"}]}],"member":"530","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0169-409X(97)00049-5","volume":"28","author":"Odonnell P. 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