{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:10:26Z","timestamp":1773681026103,"version":"3.50.1"},"reference-count":109,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol\u00edmeros"],"abstract":"<jats:p>Os diferentes sistemas de transporte t\u00eam evidenciado potencial terap\u00eautico para uma grande variedade de princ\u00edpios ativos, satisfazendo v\u00e1rios requisitos, como a preven\u00e7\u00e3o da sua elimina\u00e7\u00e3o r\u00e1pida do organismo, a redu\u00e7\u00e3o da sua toxicidade sist\u00eamica, a estabiliza\u00e7\u00e3o e a otimiza\u00e7\u00e3o do seu metabolismo, e o direcionamento espec\u00edfico ao local alvo e os mecanismos de defesa. No entanto, t\u00eam sido reconhecidos v\u00e1rios outros desafios associados \u00e0 libera\u00e7\u00e3o espec\u00edfica do princ\u00edpio ativo ao local alvo, pelo que, para ultrapassar os obst\u00e1culos qu\u00edmicos e biol\u00f3gicos, a sele\u00e7\u00e3o do pol\u00edmero utilizado para a prepara\u00e7\u00e3o do sistema de transporte \u00e9 de import\u00e2ncia crucial. O presente trabalho apresenta um relato sobre os principais pol\u00edmeros naturais e sint\u00e9ticos utilizados para a prepara\u00e7\u00e3o de sistemas de transporte de princ\u00edpios ativos in vivo.<\/jats:p>","DOI":"10.1590\/s0104-14282011005000061","type":"journal-article","created":{"date-parts":[[2011,11,23]],"date-time":"2011-11-23T01:05:14Z","timestamp":1322010314000},"page":"361-368","source":"Crossref","is-referenced-by-count":15,"title":["Pol\u00edmeros usados como sistemas de transporte de princ\u00edpios ativos"],"prefix":"10.1590","volume":"21","author":[{"given":"Patr\u00edcia","family":"Severino","sequence":"first","affiliation":[{"name":"Unicamp; UFP"}]},{"given":"Maria Helena A.","family":"Santana","sequence":"additional","affiliation":[{"name":"Unicamp"}]},{"given":"S\u00f4nia M.","family":"Malmonge","sequence":"additional","affiliation":[{"name":"UFABC"}]},{"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Unicamp; UTAD"}]}],"member":"530","published-online":{"date-parts":[[2011,11,23]]},"reference":[{"key":"ref1","volume":"72","author":"Parmar J.J","year":"2010","journal-title":"Indian J. 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