{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:04:07Z","timestamp":1774580647239,"version":"3.50.1"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol\u00edmeros"],"abstract":"<jats:p>Nanopart\u00edculas polim\u00e9ricas produzidas a partir de pol\u00edmeros sint\u00e9ticos, como copol\u00edmeros do \u00e1cido metacr\u00edlico, \u00e9steres acr\u00edlicos ou metacr\u00edlicos, t\u00eam sido amplamente utilizadas na \u00e1rea farmac\u00eautica para encapsula\u00e7\u00e3o de princ\u00edpios ativos. Essas nanopart\u00edculas apresentam as vantagens de prote\u00e7\u00e3o, libera\u00e7\u00e3o controlada, melhor biodisponibilidade e menor toxicidade, proporcionando maior conforto aos pacientes e ades\u00e3o ao tratamento. A produ\u00e7\u00e3o das nanopart\u00edculas (nanoc\u00e1psulas e nanosferas) por polimeriza\u00e7\u00e3o de mon\u00f4meros \u00e9 revisada e descrita neste artigo, evidenciando os par\u00e2metros tecnol\u00f3gicos que interferem nas caracter\u00edsticas f\u00edsico-qu\u00edmicas das nanopart\u00edculas, como a solubilidade do princ\u00edpio ativo, o volume e pH do meio de polimeriza\u00e7\u00e3o, a massa molar e concentra\u00e7\u00e3o do mon\u00f4mero e a natureza e concentra\u00e7\u00e3o do tensoativo.<\/jats:p>","DOI":"10.1590\/s0104-14282012005000006","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T23:27:03Z","timestamp":1328743623000},"page":"96-100","source":"Crossref","is-referenced-by-count":27,"title":["Prepara\u00e7\u00e3o de nanopart\u00edculas polim\u00e9ricas a partir da polimeriza\u00e7\u00e3o de mon\u00f4meros: parte I"],"prefix":"10.1590","volume":"22","author":[{"given":"Eliana B.","family":"Souto","sequence":"first","affiliation":[{"name":"UFP; Universidade de Tr\u00e1s-os-Montes e Alto Douro"}]},{"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"UFP; UNICAMP"}]},{"given":"Maria Helena A.","family":"Santana","sequence":"additional","affiliation":[{"name":"UNICAMP"}]}],"member":"530","published-online":{"date-parts":[[2012,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/wnan.15","volume":"1","author":"Nicolas J.","year":"2009","journal-title":"Rev. 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