{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:13:45Z","timestamp":1768450425495,"version":"3.49.0"},"reference-count":7,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sao Paulo Med. J."],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.<\/jats:p>","DOI":"10.1590\/s1516-31802012000100010","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T06:55:01Z","timestamp":1329288901000},"page":"57-60","source":"Crossref","is-referenced-by-count":13,"title":["Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review"],"prefix":"10.1590","volume":"130","author":[{"given":"C\u00e9sar Augusto","family":"Alvarenga","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 Manuel","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Vinagre","sequence":"additional","affiliation":[]},{"given":"Paula Itagyba","family":"Paravidino","sequence":"additional","affiliation":[]},{"given":"Marcelo","family":"Alvarenga","sequence":"additional","affiliation":[]},{"given":"Adilson","family":"Prando","sequence":"additional","affiliation":[]},{"given":"L\u00edsias Nogueira","family":"Castilho","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Athanase","family":"Billis","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Brazil"}]}],"member":"530","reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.5858\/2008-132-1272-PAEPU","article-title":"Pheochromocytoma and extra-adrenal paraganglioma: updates","volume":"132","author":"Tischler AS","year":"2008","journal-title":"Arch Pathol Lab Med."},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.5858\/133.5.811","article-title":"Paratesticular paraganglioma: a rare cause of an intrascrotal mass","volume":"133","author":"Gupta R","year":"2009","journal-title":"Arch Pathol Lab Med."},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00268-007-9360-4","article-title":"Sporadic paraganglioma","volume":"32","author":"Lee JA","year":"2008","journal-title":"World J Surg."},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1210\/jcem.86.11.8034","article-title":"Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients","volume":"86","author":"Erickson D","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12022-006-0004-2","article-title":"Histopathology and immunohistochemistry of adrenal medullary tumors and paragangliomas","volume":"17","author":"McNicol AM","year":"2006","journal-title":"Endocr Pathol."},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00364926","article-title":"The fine structure and development of the seminal vesicles and prostate in the fetal rat","volume":"109","author":"Flickinger CJ","year":"1970","journal-title":"Z Zellforsch Mikrosk Anat."},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S1470-2045(09)70164-0","article-title":"An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis","volume":"10","author":"van Nederveen FH","year":"2009","journal-title":"Lancet Oncol."}],"container-title":["Sao Paulo Medical Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/spmj\/v130n1\/a10v130n1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T08:14:48Z","timestamp":1640765688000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1516-31802012000100010&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1516-31802012000100010"],"URL":"https:\/\/doi.org\/10.1590\/s1516-31802012000100010","relation":{},"ISSN":["1516-3180"],"issn-type":[{"value":"1516-3180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}