{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:19:55Z","timestamp":1771337995414,"version":"3.50.1"},"reference-count":74,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Pharm. Sci."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Cyclodextrins (CDs) are cyclic oligosaccharides composed of D-glucopyranoside units linked by glycosidic bonds. Their main property is the ability to modify the physicochemical and biological characteristics of low-soluble drugs through the formation of drug:CD inclusion complexes. Inclusion complexation requires that host molecules fit completely or partially within the CD cavity. This adjustment is directly related to the physicochemical properties of the guest and host molecules, easy accommodation of guest molecules within the CD cavity, stoichiometry, therapeutic dose, and toxicity. However, dosage forms may achieve a high volume, depending on the amount of CD required. Thus, it is necessary to increase solubilization efficiency in order to use smaller amounts of CD. This can be achieved by adding small amounts of water-soluble polymers to the system. This review addresses aspects related to drug complexation with CDs using water-soluble polymers to optimize the amount of CD used in the formulation in order to increase drug solubility and reduce dosage form volume.<\/jats:p>","DOI":"10.1590\/s1984-82502011000400003","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T10:10:17Z","timestamp":1332929417000},"page":"665-681","source":"Crossref","is-referenced-by-count":146,"title":["Cyclodextrins and ternary complexes: technology to improve solubility of poorly soluble drugs"],"prefix":"10.1590","volume":"47","author":[{"given":"Janisse Crestani de","family":"Miranda","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}]},{"given":"T\u00e9rcio Elyan Azevedo","family":"Martins","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}]},{"given":"Francisco","family":"Veiga","sequence":"additional","affiliation":[{"name":"University of Coimbra"}]},{"given":"Humberto Gomes","family":"Ferraz","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijpharm.2006.04.002","article-title":"Implication of inclusion complexation of glimepiride in cyclodextrin-polymer systems on its dissolution, stability and therapeutic efficacy","volume":"320","author":"AMMAR H.O.","year":"2006","journal-title":"Int. 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