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We describe four critically ill patients in Taiwan who were diagnosed with multidrug\u2010resistant <jats:italic>Acinetobacter baumannii<\/jats:italic> bacteremia. All bacterial isolates from these patients were resistant to commonly available antibiotics, including carbapenems and sulbactam; however, combination therapy with a carbapenem and sulbactam led to favorable clinical outcomes in all four patients. We also conducted an in vitro study using isolates from these patients that showed that this drug combination had a synergistic effect with enhanced antibacterial activity against the isolates. Thus, a carbapenem\u2010sulbactam combination may be a therapeutic alternative for multidrug\u2010resistant <jats:italic>Acinetobacter baumannii<\/jats:italic> bacteremia in countries where colistin and tigecycline are not available for clinical use.<\/jats:p>","DOI":"10.1592\/phco.27.11.1506","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T12:21:22Z","timestamp":1193401282000},"page":"1506-1511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Combination Carbapenem\u2010Sulbactam Therapy for Critically Ill Patients with Multidrug\u2010Resistant <i>Acinetobacter baumannii<\/i> Bacteremia: Four Case Reports and an In Vitro Combination Synergy 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