{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:30:08Z","timestamp":1761093008836,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4763,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[1999,1,2]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To evaluate 24\u2010hour blood pressure control and frequency of adverse effects in patients with mild to moderate hypertension switched from nifedipine gastrointestinal therapeutic system (Nif\u2010GITS) to nifedipine coat core (Nif\u2010CC).<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> Open\u2010label, prospective, switch study.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> University\u2010affiliated outpatient cardiology clinic.<\/jats:p><jats:p><jats:bold>Subjects.<\/jats:bold> Twenty patients with mild to moderate essential hypertension, who were taking Nif\u2010GITS 30, 60, or 90 mg\/day for 8 weeks or longer.<\/jats:p><jats:p><jats:bold>Interventions.<\/jats:bold> Patients stabilized with Nif\u2010GITS 30, 60, or 90 mg were monitored over 24 hours with an ambulatory blood pressure monitor and were then switched to an equivalent dosage of Nif\u2010CC. After 8 weeks \u00b1 1 week taking Nif\u2010CC, they were again monitored with a 24\u2010hour blood pressure monitor. The 24\u2010hour blood pressure load (percentage of values &gt; 135\/85 mm Hg for 24 hrs), daytime blood pressure load (percentage of values &gt; 140\/90 mm Hg from 7:00 a.m.\u201310:00 p.m.), nighttime blood pressure load (percentage of values &gt; 120\/80 mm Hg from 10:00 p.m.\u20137:00 a.m.), diurnal blood pressure variation, average 24\u2010hour blood pressure, daytime blood pressure, nighttime blood pressure, mean blood pressure for the first 4 hours, and last 8 hours of the dosing interval were measured. Adverse effects such as headache, dizziness, and edema were also reported.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> No differences in average 24 hour\u2010blood pressure readings were observed but significant differences in blood pressure control during the first 4 and last 8 hours of the dosing interval were seen. Systolic and diastolic blood pressures were higher after approximately 16 hours in patients switched from Nif\u2010GITS to Nif\u2010CC. Although Nif\u2010CC caused a greater initial response, it was less effective than Nif\u2010GITS after 16 hours. This could explain the lack of differences in average 24\u2010hour blood pressure values between formulations. Of the 20 patients, 20% experienced increased headaches, 20% showed signs of increased peripheral edema, and 10% reported occasional dizziness after switching agents. Three patients discontinued Nif\u2010CC, two as ordered by their primary care physician and one on his own due to headache.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> This study suggests that patients switched from Nif\u2010GITS to Nif\u2010CC could experience increased blood pressure during the night or toward the end of the dosing interval. They could also experience adverse effects such as headache, edema, and dizziness, which could result in more physician visits and put patients with other disease states such as coronary heart disease at increased risk.<\/jats:p>","DOI":"10.1592\/phco.19.1.94.30512","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T05:49:43Z","timestamp":1082958583000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of 24\u2010Hour Ambulatory Blood Pressure Data in Hypertensive Patients Switched from Nifedipine\u2010GITS to Nifedipine\u2010CC"],"prefix":"10.1002","volume":"19","author":[{"given":"Richard L.","family":"Wurdeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryan N.","family":"Mooss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed M.","family":"Mohiuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"B. Daniel","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay L.","family":"Ryschon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Hilleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"issue":"6","key":"e_1_2_1_2_2","first-page":"963","article-title":"The efficacy and safety of once\u2010daily nifedipine coat\u2010core in the treatment of mild to moderate hypertension","volume":"15","author":"MacCarthy E.P.","year":"1993","journal-title":"Clin Ther"},{"issue":"6","key":"e_1_2_1_3_2","first-page":"976","article-title":"The safety and efficacy of once\u2010daily nifedipine coat\u2010core in combination with atenolol in hypertensive patients","volume":"15","author":"MacCarthy E.P.","year":"1993","journal-title":"Clin Ther"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90749-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90630-9"},{"volume-title":"Adalat CC product monograph","year":"1993","author":"Miles Inc.","key":"e_1_2_1_6_2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0149-2918(95)80003-4"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1996.tb03011.x"},{"issue":"3","key":"e_1_2_1_9_2","first-page":"364","article-title":"An open\u2010label study examining the effects of switching patients with stage I\u2010II hypertension controlled on nifedipine gastrointestinal therapeutic system (GITS) to nifedipine coat\u2010core (CC) [abstr]","volume":"15","author":"Lucas B.D.","year":"1995","journal-title":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"},{"issue":"3","key":"e_1_2_1_10_2","first-page":"401","article-title":"A calcium channel antagonist target drug program in a group model health maintenance organization [abstr]","volume":"15","author":"Witt D.M.","year":"1995","journal-title":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90593-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92867-X"},{"issue":"8","key":"e_1_2_1_13_2","first-page":"S42","article-title":"Dippers versus non\u2010dippers","volume":"9","author":"Verdecchia P.","year":"1991","journal-title":"J Hypertens"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.16.6.692"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.528"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.6.793"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90611-K"},{"first-page":"212","volume-title":"United States USP dispensing information","year":"1998","key":"e_1_2_1_18_2"},{"issue":"6","key":"e_1_2_1_19_2","first-page":"1002","article-title":"Conversion from sustained\u2010release to immediate\u2010release calcium entry blockers: outcome in patients with mild\u2010to\u2010moderate hypertension","volume":"15","author":"Hilleman D.E.","year":"1993","journal-title":"Clin Ther"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809703100701"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.19.1.94.30512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.19.1.94.30512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:17:38Z","timestamp":1761041858000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.19.1.94.30512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1,2]]}},"alternative-id":["10.1592\/phco.19.1.94.30512"],"URL":"https:\/\/doi.org\/10.1592\/phco.19.1.94.30512","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[1999,1,2]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}