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Key features include early\u2010onset, persistent, well\u2010formed, visual hallucinations and motor features of parkinsonism. Pharmacologic management of neurobehavioral symptoms is complicated by an exaggerated response to neuroleptics, which causes excessive morbidity and mortality. Patients with dementia with Lewy bodies may be particularly responsive to cholinesterase inhibitors. When neurobehavioral symptoms are severe enough to require pharmacologic intervention, it is recommended that agents such as trazodone or cholinesterase inhibitors be considered first\u2010line therapy. If these fail, neuroleptics may be prescribed with caution.<\/jats:p>","DOI":"10.1592\/phco.19.10.795.31555","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T04:25:07Z","timestamp":1083903907000},"page":"795-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dementia with Lewy Bodies: Review and Pharmacotherapeutic Implications"],"prefix":"10.1002","volume":"19","author":[{"given":"Carlos H.","family":"Rojas\u2010Fernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"MacKnight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"51","volume-title":"Clinical diagnosis and management of Alzheimer's disease","author":"Pryse\u2010Phillips W.","year":"1996"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_2","DOI":"10.1001\/jama.1997.03550160083043"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1159\/000026219"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1001\/archinte.1996.00440050031004"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_2","DOI":"10.1212\/WNL.47.5.1113"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1212\/WNL.40.10.1523"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_2","DOI":"10.1136\/bmj.305.6855.673"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_2","DOI":"10.1016\/S0140-6736(95)92307-1"},{"key":"e_1_2_1_10_2","first-page":"851","article-title":"Assessing dementia: the Canadian consensus","volume":"144","author":"Organizing Committee, Canadian Consensus Conference on the Assessment of Dementia","year":"1991","journal-title":"Can Med Assoc J"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_2","DOI":"10.2165\/00002512-199710050-00005"},{"doi-asserted-by":"publisher","key":"e_1_2_1_12_2","DOI":"10.1212\/WNL.48.2.376"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_2","DOI":"10.1136\/jnnp.62.3.243"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_2","DOI":"10.1212\/WNL.51.2.351"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_2","DOI":"10.1093\/ageing\/25.3.209"},{"doi-asserted-by":"publisher","key":"e_1_2_1_16_2","DOI":"10.1212\/WNL.46.3.682"},{"issue":"1","key":"e_1_2_1_17_2","first-page":"51S","article-title":"From transmitters to treatment: the pharmacotherapy of behavioral disturbances in dementia","volume":"42","author":"Herrmann N.","year":"1997","journal-title":"Can J Psychiatry"},{"doi-asserted-by":"publisher","key":"e_1_2_1_18_2","DOI":"10.2165\/00002512-199812020-00004"},{"doi-asserted-by":"publisher","key":"e_1_2_1_19_2","DOI":"10.1017\/S0033291700038484"},{"doi-asserted-by":"publisher","key":"e_1_2_1_20_2","DOI":"10.1016\/S0140-6736(95)91245-2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_21_2","DOI":"10.1016\/S0140-6736(05)78999-6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_22_2","DOI":"10.1056\/NEJM198908033210507"},{"issue":"2","key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0749-0690(18)30616-5","article-title":"Altered pharmacodynamics in the elderly","volume":"6","author":"Feely J.","year":"1990","journal-title":"Clin Geriatr Med"},{"issue":"8904","key":"e_1_2_1_24_2","first-page":"1044","article-title":"Dopamine D2 receptors in demented patients with severe neuroleptic sensitivity [letter]","volume":"343","author":"Piggot MA","year":"1994","journal-title":"Lancet"},{"doi-asserted-by":"publisher","key":"e_1_2_1_25_2","DOI":"10.1111\/j.1749-6632.1991.tb00217.x"},{"doi-asserted-by":"publisher","key":"e_1_2_1_26_2","DOI":"10.1097\/00002093-199040200-00003"},{"doi-asserted-by":"publisher","key":"e_1_2_1_27_2","DOI":"10.1016\/S0006-3223(98)00127-9"},{"issue":"4","key":"e_1_2_1_28_2","first-page":"78","article-title":"Practical solutions to polypharmacy problems in the elderly","volume":"15","author":"Gordon J.","year":"1998","journal-title":"Can J Diagn"},{"issue":"5","key":"e_1_2_1_29_2","first-page":"359","article-title":"The aging liver. 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