{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:52:59Z","timestamp":1787849579139,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>Dong quai is a Chinese herbal supplement touted for treatment of menstrual cramping, irregular menses, and menopausal symptoms. Phytochemical analyses found it to consist of natural coumarin derivatives, as well as constituents possessing antithrombotic, antiarrhythmic, phototoxic, and carcinogenic effects. A 46\u2010year\u2010old African\u2010American woman with atrial fibrillation stabilized on warfarin experienced a greater than 2\u2010fold elevation in prothrombin time and international normalized ratio after taking dong quai concurrently for 4 weeks. No identifiable cause was ascertained for the increase except dong quai. The patient's coagulation values returned to acceptable levels 1 month after discontinuing the herb. One animal study suggests a pharmacodynamic interaction between the product and warfarin, but the true mechanism remains unknown. Practitioners should be aware of the possibility of such an interaction and should inform patients of potential hazards of taking the two together.<\/jats:p>","DOI":"10.1592\/phco.19.10.870.31558","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T04:25:07Z","timestamp":1083903907000},"page":"870-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Potentiation of Warfarin by Dong Quai"],"prefix":"10.1002","volume":"19","author":[{"suffix":"II","given":"Robert Lee","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1056\/NEJM199301283280406","article-title":"Unconventional medicine in the united states:prevalence, costs, and patterns of use","volume":"328","author":"Eisenberg DM","year":"1993","journal-title":"N Engl J Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520320015008"},{"key":"e_1_2_1_4_2","first-page":"390","article-title":"Nature's medicinal bounty: don't throw it away","volume":"14","author":"Akerele O.","year":"1993","journal-title":"World Health Forum"},{"key":"e_1_2_1_5_2","first-page":"15","article-title":"The right stuff: Drug Store News picks the categories taking off in \u201894","volume":"16","year":"1994","journal-title":"Drug Store News"},{"key":"e_1_2_1_6_2","first-page":"1","volume-title":"Herbal medicine: an introduction for pharmacists","author":"Brown DJ","year":"1997"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/875512259501100510"},{"key":"e_1_2_1_8_2","unstructured":"Top health frauds 1996 FDA backgrounder: current and useful information from the Food & Drug Administration"},{"key":"e_1_2_1_9_2","first-page":"1","volume-title":"The review of natural products. Dong quai","author":"Hebel SK","year":"1997"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X87000151"},{"key":"e_1_2_1_11_2","first-page":"776","article-title":"Advances in the pharmacological studies of Radix Angelica sinensis (OLIV) Diels (Chinese danggui)","volume":"104","author":"Qi\u2010Bing M.","year":"1991","journal-title":"Chin Med J"},{"key":"e_1_2_1_12_2","first-page":"329","volume-title":"Chinese herbal medicine: materia medica","author":"Gamble A.","year":"1993"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1997.tb03786.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510390082038"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00397-X"},{"key":"e_1_2_1_16_2","first-page":"20","article-title":"The phyto\u2010oestrogen debate","volume":"2","author":"Wilbur P.","year":"1996","journal-title":"Eur J Herbal Med"},{"key":"e_1_2_1_17_2","first-page":"282","volume-title":"Chinese Herbal Medicine: formulas and Strategies","author":"Bensky D.","year":"1990"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-962742"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.29b-0757"},{"key":"e_1_2_1_20_2","volume-title":"The honest herbal:a sensible guide to the use of herbs and related remedies","author":"Tyler VE","year":"1993"},{"key":"e_1_2_1_21_2","volume-title":"Herbal medicines: a guide for health\u2010care professionals","author":"Newall CA","year":"1996"},{"issue":"6","key":"e_1_2_1_22_2","first-page":"321","article-title":"The effect of danggui (Angelica sinensis) and its ingredient ferulic acid on rat platelet aggregation and release of 5\u2010HT","volume":"15","author":"Yin ZZ","year":"1980","journal-title":"Acta Pharma Sinica"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(95)02112-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502901214"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1055\/s-0038-1651041","article-title":"Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens","volume":"62","author":"Ko FN","year":"1989","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_26_2","first-page":"414","article-title":"Studies on the mechanism of the antiplatelet effect of sodium ferulate on TXA2\/PGI2","volume":"6","author":"Xu LN","year":"1984","journal-title":"Acta Acad Med Sin"},{"key":"e_1_2_1_27_2","first-page":"263","article-title":"Effects of sodium ferulate on platelet aggregation and platelet thromboxane A2 in patients with coronary heart disease","volume":"8","author":"Gao SW","year":"1988","journal-title":"Chin J Mod Dev Tradit Med"},{"key":"e_1_2_1_28_2","first-page":"430","article-title":"Sodium ferulate is an inhibitor of thromboxane A2 synthetase","volume":"9","author":"Wang Z.","year":"1988","journal-title":"Acta Pharm Sin"},{"key":"e_1_2_1_29_2","first-page":"225","article-title":"Effects of Radix Angelicae sinensis on hemorrheology in patients with acute ischemic stroke","volume":"4","author":"Junjie T.","year":"1984","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03192289"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958145"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1039\/np9971400465"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00045-9"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957985"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-2-165"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.19.10.870.31558","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.19.10.870.31558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:53:32Z","timestamp":1761054812000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.19.10.870.31558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1592\/phco.19.10.870.31558"],"URL":"https:\/\/doi.org\/10.1592\/phco.19.10.870.31558","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}