{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:54:37Z","timestamp":1783137277984,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4552,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>A 67\u2010year\u2010old woman with metastatic breast cancer experienced sudden and profound pulmonary edema within 45 minutes after completion of intravenous administration of vinorelbine tartrate on two occasions. Both times the drug was discontinued and the patient was treated aggressively with oxygen, intravenous furosemide, and a vasodilator. The patient suffered no lasting medical complications due to the reaction. Until clear documentation and the mechanism for occurrence of this reaction are known, patients receiving vinorelbine should be monitored closely, particularly in the first few hours after intravenous administration.<\/jats:p>","DOI":"10.1592\/phco.19.11.992.31580","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T05:37:25Z","timestamp":1083908245000},"page":"992-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Vinorelbine Tartrate\u2010Induced Pulmonary Edema Confirmed on Rechallenge"],"prefix":"10.1002","volume":"19","author":[{"given":"Christine E.","family":"Cattan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin C.","family":"Oberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000216938"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30192-8"},{"key":"e_1_2_1_4_2","first-page":"42","article-title":"A summery of vinorelbine (Navelbine) safety data from North American clinical trials","volume":"21","author":"Hohneker JA","year":"1994","journal-title":"Semin Oncol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.7.1245"},{"key":"e_1_2_1_7_2","first-page":"14","article-title":"Summary of data from in vitro and phase I vinorelbine (Navelbine) studies","volume":"21","author":"Burris HA","year":"1994","journal-title":"Semin Oncol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821215)50:12<2771::AID-CNCR2820501213>3.0.CO;2-T"},{"key":"e_1_2_1_9_2","first-page":"5121","article-title":"Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions","volume":"53","author":"Zhou\u2010Pan XR","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.3.846"},{"key":"e_1_2_1_11_2","first-page":"1259","article-title":"Acute pulmonary edema induced by vinorelbine","volume":"25","author":"Vaylet F.","year":"1996","journal-title":"[Oedema aigu du poumon apres vinorelbine.] Presse Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010803"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1200\/JCO.1995.13.2.531","article-title":"Myocardial ischemia and infarction associated with vinorelbine","volume":"13","author":"Bergeron A.","year":"1995","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00141-4"},{"key":"e_1_2_1_15_2","first-page":"299","article-title":"Myocardial infarction and vinorelbine. Report of a case. [Infarctus myocardique et vinorelbine. Rapport d'un cas]","volume":"8","author":"Dubos C.","year":"1991","journal-title":"Rev Mal Respir"},{"key":"e_1_2_1_16_2","first-page":"94","article-title":"Coronary disease and vinorelbine. [Insuffisance coronarienne et vinorelbine]","volume":"50","author":"Ruffenach M.","year":"1994","journal-title":"Rev Pneumol Clin"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.19.11.992.31580","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.19.11.992.31580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:52:17Z","timestamp":1761061937000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.19.11.992.31580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["10.1592\/phco.19.11.992.31580"],"URL":"https:\/\/doi.org\/10.1592\/phco.19.11.992.31580","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}