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The mean time to neutrophil recovery was 4.6 \u00b1 3.2 days and 7.7 \u00b1 5.1 days in patients with a granulocyte count at diagnosis of 0.1\u20100.5 \u00d7 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup> and less than 0.1 \u00d7 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>, respectively. The mortality rate was 4.2%. Without therapy with growth factors, the mean time to neutrophil recovery after discontinuation of the offending agent was reported to be 10 \u00b1 8 days. The mortality rate was 16% in one study. We conclude that hematopoietic growth factors may shorten the duration of neutropenia and reduce mortality in patients with severe drug\u2010induced agranulocytosis.<\/jats:p>","DOI":"10.1592\/phco.19.4.299.30941","type":"journal-article","created":{"date-parts":[[2004,4,27]],"date-time":"2004-04-27T10:55:45Z","timestamp":1083063345000},"page":"299-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Nonchemotherapy Drug\u2010Induced Agranulocytosis: A Review of 118 Patients Treated with Colony\u2010Stimulating Factors"],"prefix":"10.1002","volume":"19","author":[{"given":"Marie\u2010France","family":"Beauchesne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen 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