{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:35:08Z","timestamp":1782902108303,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4399,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>Muromonab\u2010CD3 (OKT3), a murine IgG2a antibody directed against the T3 (CD3) complex on mature lymphocytes, triggers adverse immune reactions. Anaphylactic reactions have occurred in patients exposed to OKT3 and are mediated by anti\u2010OKT3 IgE antibodies. The reactions are not antibody mediated and can occur within seconds of administration of a mast cell secretogogue. A renal transplant recipient became hypotensive and hypoxic immediately after receiving her first dose of OKT3 and required advanced life support. Serum antibody tests were negative for anti\u2010OKT3 IgG, IgE, and antimouse protein antibodies. To our knowledge, this is the first published report of a patient with an anaphylactoid reaction to the initial infusion of OKT3.<\/jats:p>","DOI":"10.1592\/phco.20.1.100.34666","type":"journal-article","created":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T10:27:54Z","timestamp":1086863274000},"page":"100-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anaphylactoid Reaction to Muromonab\u2010CD3 in a Pediatric Renal Transplant Recipient"],"prefix":"10.1002","volume":"20","author":[{"given":"Robert J.","family":"Berkowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Possidente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart V.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1399-0012.1993.tb01129.x","article-title":"Adverse events associated with OKT3 immunosuppression in the prevention or treatment of allograft rejection","volume":"7","author":"Kreis H.","year":"1993","journal-title":"Clin Transplant"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03123-W"},{"key":"e_1_2_1_4_2","volume-title":"Orthoclone OKT3 (muromonab\u2010CD3) package insert","author":"Ortho Biotech Inc","year":"1995"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199651050-00010"},{"key":"e_1_2_1_6_2","first-page":"736","article-title":"Anaphylactic shock after retreatment with OKT3 monoclonal antibody [letter]","volume":"7","author":"Abramowicz D.","year":"1992","journal-title":"N Eng J Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93028-8"},{"key":"e_1_2_1_8_2","first-page":"343","article-title":"Anaphylaxis and desensitization to the murine monoclonal antibody used for renal graft rejection","volume":"66","author":"Georgitis JW","year":"1991","journal-title":"Ann Allergy"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0012.1993.tb00865.x","article-title":"Late reactions during OKT3 treatment","volume":"7","author":"Turner MC","year":"1993","journal-title":"Clin Transplant"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198810000-00011"},{"key":"e_1_2_1_11_2","first-page":"16","volume-title":"Illustrated dictionary of immunology","author":"Cruse J.","year":"1995"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508083130601"},{"issue":"2","key":"e_1_2_1_13_2","first-page":"16","article-title":"General aspects of cytokine\u2010release syndrome: timing and frequency of symptoms","volume":"25","author":"Jeyarajah DR","year":"1993","journal-title":"Transplant Proc"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199102000-00012"},{"key":"e_1_2_1_15_2","first-page":"123","article-title":"The complications of newer transplant antirejection drugs: treatment with cyclosporin A, OKT3, and FK506","volume":"9","author":"Li PKT","year":"1990","journal-title":"Adverse Drug React Acute Poison Rev"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199010000-00023"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199602270-00011"},{"key":"e_1_2_1_18_2","first-page":"543","article-title":"RAST with animal dander, urine, saliva and serum","volume":"51","author":"Berrens L.","year":"1983","journal-title":"Ann Allergy"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90233-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1974.tb01990.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659409011065"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659509000472"},{"key":"e_1_2_1_23_2","first-page":"439","article-title":"Nearly fatal episodes of hypotension, flushing and dyspnea in a 47\u2010year\u2010old woman","volume":"70","author":"Doan T.","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6500.938"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315581"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63352-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198311000-00028"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310310049024"},{"key":"e_1_2_1_29_2","first-page":"302","article-title":"Anaphylaxis\u2010like reactions to corticosteroid therapy","volume":"54","author":"Mendelson LM","year":"1985","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198909000-00047"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90963-X"},{"issue":"8","key":"e_1_2_1_32_2","first-page":"417","article-title":"Causes of anaphylactoid reactions in cattle after administration of lipoid preparations","volume":"37","author":"Toman M.","year":"1992","journal-title":"Vet Med (Praha)"},{"issue":"1","key":"e_1_2_1_33_2","first-page":"27","article-title":"Convulsions and death induced in rats by Tween 80 are prevented by capsaicin","volume":"18","author":"Dib B.","year":"1996","journal-title":"Int J Tissue React"},{"issue":"1","key":"e_1_2_1_34_2","first-page":"129","article-title":"Orthoclone OKT3 treatment of acute renal allograft rejection","volume":"17","author":"Goldstein G.","year":"1985","journal-title":"Transplant Proc"},{"issue":"1","key":"e_1_2_1_35_2","first-page":"12","article-title":"OKT3: first\u2010dose safety and success","volume":"46","author":"Cosimi AB","year":"1987","journal-title":"Nephrology"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<2123::AID-CNCR24>3.0.CO;2-W"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(97)00161-4"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63184-5"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80254-X"},{"key":"e_1_2_1_40_2","first-page":"1645","volume-title":"Diseases of the kidney","author":"Schrier RW","year":"1997"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.20.1.100.34666","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.20.1.100.34666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:05:59Z","timestamp":1761041159000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.20.1.100.34666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1592\/phco.20.1.100.34666"],"URL":"https:\/\/doi.org\/10.1592\/phco.20.1.100.34666","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}