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Several companion drugs, including steroids, diphenhydramine, histamine<jats:sub>2<\/jats:sub> blockers, serotonin type 3 antagonists, and other chemotherapeutic agents administered with paclitaxel, must be considered as possible causes of pancreatitis. In addition, paclitaxel is a hydrophobic agent that requires a vehicle, cremophor (CrEL), for solubility. Intravenous cyclosporine also requires CrEL and has been associated with pancreatitis. In the cerulein\u2010induced pancreatitis rat model, paclitaxel with dimethyl sulfoxide as a vehicle prevents pancreatitis, suggesting that another causal agent is responsible. Animal studies of CrEL as a single agent may be required to settle this question, but for now, awareness that paclitaxel may be associated with pancreatitis may lead to earlier treatment of this potentially fatal complication.<\/jats:p>","DOI":"10.1592\/phco.20.1.95.34653","type":"journal-article","created":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T10:27:54Z","timestamp":1086863274000},"page":"95-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Possible Drug\u2010Associated Pancreatitis after Paclitaxel\u2010Cremophor Administration"],"prefix":"10.1002","volume":"20","author":[{"given":"Kimberly M.","family":"Mills","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Middlebrooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary V.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00254-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.1.91"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199607000-00014"},{"issue":"2","key":"e_1_2_1_5_2","first-page":"141","article-title":"Steroids revisited. 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