{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:35:17Z","timestamp":1792658117948,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4064,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p><jats:bold>Study Objectives.<\/jats:bold> To determine whether antipyretic therapy prolongs the course of experimental influenza A, <jats:italic>Shigella sonnei<\/jats:italic>, and <jats:italic>Rickettsia rickettsii<\/jats:italic> infections.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> Retrospective observational study.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> University Center for Vaccine Development.<\/jats:p><jats:p><jats:bold>Subjects.<\/jats:bold> Fifty\u2010four volunteers with experimentally induced influenza A, 45 with <jats:italic>S. sonnei<\/jats:italic>, and 21 with <jats:italic>R. rickettsii<\/jats:italic> infections participated.<\/jats:p><jats:p><jats:bold>Interventions.<\/jats:bold> Subjects from the six influenza A studies were challenged intranasally. If they met certain criteria, they were offered aspirin or acetaminophen for symptomatic relief. Subjects from the three <jats:italic>Shigella<\/jats:italic> studies were challenged with the bacteria and then given trimethoprim\u2010sulfamethoxazole. Acetaminophen also could be administered. In the one <jats:italic>R. rickettsii<\/jats:italic> trial, subjects were inoculated intradermally and treated with tetracycline. Again, acetaminophen was administered for symptomatic relief.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> Data, excerpted from subjects' study records, were evaluated using Wilcoxon tests, Spearman's correlation coefficients, and multiple regression analysis. Two\u2010tailed hypotheses with a value of 0.05 were used for all of the analyses. There was a striking correlation between antipyretic therapy and duration of illness in subjects infected with influenza A and <jats:italic>S. sonnei<\/jats:italic>, but not <jats:italic>R. rickettsii<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Multivariate analysis suggested that antipyretic therapy prolonged illness in subjects infected with influenza A, but its use was the result of prolonged illness in those infected with <jats:italic>S. sonnei<\/jats:italic>. The precise nature of these relationships requires a prospective, randomized, placebo\u2010controlled trial.<\/jats:p>","DOI":"10.1592\/phco.20.19.1417.34865","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T15:22:20Z","timestamp":1087312940000},"page":"1417-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Effect of Antipyretic Therapy on the Duration of Illness in Experimental Influenza A, <i>Shigella sonnei<\/i>, and <i>Rickettsia rickettsii<\/i> Infections"],"prefix":"10.1002","volume":"20","author":[{"given":"Karen I.","family":"Plaisance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneel","family":"Kudaravalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron M.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Mackowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08328.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.17.1870"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240240018017"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80461-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.6.1277"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1128\/iai.32.2.693-697.1981","article-title":"Evaluation of A\/Alaska\/6\/77 (H3N2) cold\u2010adapted recombinant viruses derived from the A\/Ann Arbor\/6\/60 cold\u2010adapted donor virus in adult seronegative volunteers","volume":"32","author":"Murphy BR","year":"1980","journal-title":"Infect Immun"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.6.1260"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(90)90094-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.5.922"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1128\/br.30.2.408-417.1966","article-title":"Symposium on in vitro studies of the immune response. 3. 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