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She also received phenytoin for posttraumatic seizures. Acetaminophen was discontinued, and the patient's liver chemistries returned to normal within 2 weeks of discharge. Acetaminophen is metabolized in part by cytochrome P450 (CYP) 2E1, and inducers of CYP2E1 are known to predispose patients to acetaminophen\u2010related hepatotoxicity. Phenytoin induces CYP2C and CYP3A4 isoforms, but not CYP2E1. The literature suggests, however, that CYP3A4 may participate in acetaminophen metabolism to a greater extent than previously realized, and induction of this isoform may predispose patients to acetaminophen\u2010induced hepatotoxicity.<\/jats:p>","DOI":"10.1592\/phco.20.3.229.34774","type":"journal-article","created":{"date-parts":[[2004,6,14]],"date-time":"2004-06-14T06:56:42Z","timestamp":1087196202000},"page":"229-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Phenytoin as a Possible Cause of Acetaminophen Hepatotoxicity: Case Report and Review of the Literature"],"prefix":"10.1002","volume":"20","author":[{"given":"Carolyn C.","family":"Brackett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1070942"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1981.tb09831.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1984.tb04999.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-646"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00558513"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220312"},{"key":"e_1_2_1_8_2","first-page":"70","volume-title":"Pharmacotherapy: a pathophysiologic approach","author":"Chyka PA","year":"1999"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/00325481.1992.11701256","article-title":"Recognizing acetaminophen hepatotoxicity in chronic alcoholics","volume":"91","author":"Rex DK","year":"1992","journal-title":"Postgrad Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8081"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198802000-00016"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290109"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.2.408"},{"key":"e_1_2_1_14_2","first-page":"590","article-title":"Acetaminophen hepatotoxicity: potentiation by isoniazid","volume":"88","author":"Crippin JS","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93063-U"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/096032718800700106"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050132"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17332"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb00922.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1981.tb01175.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1984.64"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90278-6"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2215"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90295-8"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.20.3.229.34774","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.20.3.229.34774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:37:13Z","timestamp":1761039433000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.20.3.229.34774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1592\/phco.20.3.229.34774"],"URL":"https:\/\/doi.org\/10.1592\/phco.20.3.229.34774","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}