{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:58:01Z","timestamp":1761764281298,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4308,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To assess the relationship between the occurrence of benign prostatic hyperplasia (BPH), an androgen\u2010dependent disease, and coronary artery disease (defined as history of coronary artery bypass grafting, coronary angioplasty, myocardial infarction) in elderly men.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> Retrospective chart review.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> Urology practice.<\/jats:p><jats:p><jats:bold>Patients.<\/jats:bold> Seven hundred two elderly men aged 65\u201380 years.<\/jats:p><jats:p><jats:bold>Intervention.<\/jats:bold> The men's charts were reviewed for data pertaining to coronary artery disease, risk factors for coronary artery disease, and serum prostate\u2010specific antigen (PSA) levels. Men who had medical conditions, pharmacologic interventions, or surgical procedures that could alter PSA, and those taking lipid\u2010lowering agents were not included.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> PSA levels correlate positively with prostatic volume of BPH. In men with levels under 1.0 \u03bcg\/L (no BPH) and over 1.0 \u03bcg\/L (BPH present), the frequency of coronary artery disease was 9% and 29%, respectively (p&lt;0.03). No significant differences were noted between groups in other accepted risk factors for coronary artery disease including age, smoking, diabetes mellitus, or hypertension.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> Smooth muscle proliferation is an important and possibly androgen\u2010dependent step in the development of atherosclerosis and BPH. 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