{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:49:11Z","timestamp":1761162551762,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":4217,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>Amiodarone is a class III antiarrhythmic agent that is effective in treating different types of cardiac dysrhythmias. It was approved only for treatment of life\u2010threatening ventricular dysrhythmias refractory to other therapy; however, its use for atrial dysrhythmias such as atrial fibrillation is well accepted. Adverse effects associated with amiodarone include pulmonary, hepatic, thyroid, ocular, and neurologic toxicities. Our patient experienced intermittent fever, night sweats, and fatigue while taking the drug for treatment of atrial fibrillation. Bone marrow biopsy showed granuloma formation after 17 months of therapy with amiodarone. Amiodarone was discontinued due to significant hypotension and shortness of breath. To our knowledge, this is the third case report of granuloma formation in bone marrow possibly associated with this agent.<\/jats:p>","DOI":"10.1592\/phco.20.9.855.35204","type":"journal-article","created":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T15:41:31Z","timestamp":1087400491000},"page":"855-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bone Marrow Granulomas Possibly Associated with Amiodarone"],"prefix":"10.1002","volume":"20","author":[{"given":"Weeranuj","family":"Yamreudeewong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsieh J.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Ranelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1984.tb01822.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(81)90140-X"},{"key":"e_1_2_1_4_2","first-page":"1370","volume-title":"AHFS drug information 1999","author":"McEvoy G.K.","year":"1999"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80367-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1983.tb05340.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-7-199410010-00009"},{"issue":"2","key":"e_1_2_1_8_2","first-page":"76S","article-title":"Class III antiarrhythmic agents: the next wave","volume":"17","author":"Bauman J.L.","year":"1997","journal-title":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00717-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91895-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200001000-00009"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01027-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90321-X"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5858\/1999-123-0251-SICCBA","article-title":"Severe intrahepatic cholestasis caused by amiodarone toxicity after withdrawal of the drug. A case report and review of the literature","volume":"123","author":"Chang C.C.","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-1-199701010-00009"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00220-9"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(89)90016-9"},{"key":"e_1_2_1_18_2","first-page":"50","volume-title":"Robbins' pathologic basis of disease","author":"Collins T.","year":"1999"},{"key":"e_1_2_1_19_2","first-page":"43","article-title":"Bone marrow granuloma: clinicopathologic findings in 72 cases and review of the literature","volume":"2","author":"Bhargava V.","year":"1988","journal-title":"Hematol Pathol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17061"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90208-M"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1989.tb03352.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430893"},{"key":"e_1_2_1_24_2","first-page":"1753","article-title":"Sepsis syndrome and bone marrow granulomatosis after intravesical instillation of BCG","volume":"28","author":"Andres E.","year":"1999","journal-title":"Presse Med"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198311000-00003"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1993.3.305"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199408000-00019"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199243010-00007"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90006-6"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.20.9.855.35204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.20.9.855.35204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:01:12Z","timestamp":1761066072000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.20.9.855.35204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1592\/phco.20.9.855.35204"],"URL":"https:\/\/doi.org\/10.1592\/phco.20.9.855.35204","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}