{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:32:35Z","timestamp":1780057955322,"version":"3.54.0"},"reference-count":31,"publisher":"Wiley","issue":"10P2","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":2298,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>The growing threat posed by antibiotic\u2010resistant pathogens is a major challenge for infectious disease practitioners and public health officials. In recent years, the prevalence of resistance among key bacterial pathogens, including <jats:italic>Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Streptococcus pneumoniae<\/jats:italic>, and <jats:italic>Enterococcus<\/jats:italic> sp, has increased at an alarming rate. The impact of antimicrobial resistance is manifold and can ultimately lead to treatment failure and increased morbidity and mortality. To control the spread of resistance and subsequent impact, a multifaceted approach is warranted. Awareness and surveillance of antimicrobial resistance, prudent use of antibiotics, and compliance with infection control techniques may help contain the emergence and spread of resistant organisms.<\/jats:p>","DOI":"10.1592\/phco.2005.25.10part2.44s","type":"journal-article","created":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T04:49:43Z","timestamp":1128919783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antimicrobial Resistance in the Hospital Setting: Impact, Trends, and Infection Control Measures"],"prefix":"10.1002","volume":"25","author":[{"given":"Gary E.","family":"Stein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/513766"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/344654"},{"key":"e_1_2_1_4_2","unstructured":"World Health Organization.Overcoming antimicrobial resistance: world health report on infectious diseases 2000. Available fromhttp:www.who.intinfectious\u2010disease\u2010report2000other_versionindex\u2010rpt2000_text.html. Accessed May 18 2005."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2002.130391"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/427701"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-3-14"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.25.1.74.55620"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.21.11.920.34529"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-001-0054-z"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/322667"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.07.010"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.09.015"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0702.010203"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3222-3232.2003"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.118-125.2005"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2431-2436.2004"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4606-4610.2004"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-644ST"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh506"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.392-395.2004"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/374052"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3491-3497.2004"},{"issue":"3","key":"e_1_2_1_26_2","first-page":"S3","article-title":"Streptococcus pneumoniae: epidemiology and patterns of resistance","volume":"117","author":"Jacobs MR","year":"2004","journal-title":"Am J Med"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/381886"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/321815"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1619-1628.2002"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421007"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/382086"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1086\/502267"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.2005.25.10part2.44S","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.2005.25.10part2.44S","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:30:37Z","timestamp":1761053437000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.2005.25.10part2.44S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":31,"journal-issue":{"issue":"10P2","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1592\/phco.2005.25.10part2.44S"],"URL":"https:\/\/doi.org\/10.1592\/phco.2005.25.10part2.44s","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}