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Most strains producing these \u03b2\u2010lactamases are <jats:italic>Klebsiella pneumoniae<\/jats:italic>, other <jats:italic>Klebsiella<\/jats:italic> species (i.e., <jats:italic>K. oxytoca<\/jats:italic>), and <jats:italic>Escherichia coli<\/jats:italic>. When producing these enzymes, organisms become highly effective at inactivating various \u03b2\u2010lactam antibiotics. In addition, ESBL\u2010producing bacteria are frequently resistant to many classes of antibiotics, resulting in difficult\u2010to\u2010treat infections. Other problems due to ESBL\u2010producing bacteria are difficulty in detecting the presence of ESBLs, limited treatment options, and deleterious impact on clinical outcomes. 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