{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:59:31Z","timestamp":1761487171004,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3699,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>\n                    <jats:bold>Study Objective.<\/jats:bold>\n                    To compare the effectiveness of single daily dosing (SDD) versus conventional dosing of gentamicin when administered with penicillin to treat enterococcal infections.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design.<\/jats:bold>\n                    In vitro pharmacodynamic model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting.<\/jats:bold>\n                    Hospital laboratory.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Measurements and Main Results.<\/jats:bold>\n                    A 24\u2010hour in vitro pharmacodynamic model was employed to simulate SDD and 3 times\/day dosing of gentamicin, in conjunction with continuously infused penicillin, against\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    . Duplicate 24\u2010hour kill curves were generated with varying concentrations of penicillin and gentamicin alone and in combination. No difference in the rate of kill was seen between any combination of penicillin and gentamicin. Regrowth occurred only with drug combinations in which penicillin was administered continuously at the minimum inhibitory concentration. Variations in the gentamicin dosing regimen did not affect regrowth.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    In the treatment of enterococcal infections, an SDD regimen for gentamicin shows no efficacy benefit compared with conventional dosing.\n                  <\/jats:p>","DOI":"10.1592\/phco.21.20.1479.34476","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T05:27:33Z","timestamp":1086758853000},"page":"1479-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In Vitro Pharmacodynamic Analysis of Single Daily Dosing versus Conventional Dosing of Gentamicin Administered with Penicillin Against\n                    <i>Enterococcus faecalis<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Gigi H.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie Baeker","family":"Hovde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir H.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Rotschafer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1762"},{"key":"e_1_2_1_3_2","first-page":"740","volume-title":"Principles and practice of infectious diseases","author":"Scheld WM","year":"1995"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530210060032"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000238747"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.2.281"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/27.suppl_C.49"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/313692"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.5.820"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1128\/AAC.43.7.1549","article-title":"Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity","volume":"43","author":"Rybak MJ","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.3.399"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.3.650"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90137-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)80074-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1998.00224.x"},{"volume-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, 3rd ed","year":"1993","author":"National Committee for Clinical Laboratory Standards.","key":"e_1_2_1_16_2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.6.1377"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1166"},{"key":"e_1_2_1_19_2","first-page":"321","article-title":"Assay of 27 antimicrobials using a microbiological method","volume":"66","author":"Peterson LR","year":"1983","journal-title":"Minn Med"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1977213362"},{"key":"e_1_2_1_21_2","first-page":"1103","volume-title":"Goodman & Gilman's the pharmacological basis of therapeutics","author":"Chambers HF","year":"1995"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.16.1252.30876"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18316"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.20.13.1116.35029"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.3.611"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0891-5520(20)30279-8","article-title":"Pharmacodynamics of antimicrobial agents: bactericidal and postantibiotic effects","volume":"3","author":"Levison ME","year":"1989","journal-title":"Infect Dis Clin North Am"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.1.93"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80754-5"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1977.03630230050014"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/jama.1973.03220090050011","article-title":"Penicillin and gentamicin therapy for enterococcal infections","volume":"223","author":"Weinstein AJ","year":"1973","journal-title":"JAMA"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-6-816"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/27.suppl_C.41"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112463"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.4"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.5.796"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.5.786"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00244-7"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.5.810"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.12.2387"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.4.519"},{"key":"e_1_2_1_41_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/AAC.40.1.173","article-title":"Treatment of experimental endocarditis due to Enterococcus faecalis using once\u2010daily regimen of gentamicin plus simulated profiles of ampicillin in human serum","volume":"40","author":"Gavalda J","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1128\/AAC.40.10.2258","article-title":"Once\u2010 versus thrice\u2010daily netilmicin combined with amoxicillin, penicillin, or vancomycin against Enterococcus faecalis in a pharmacodynamic in vitro model","volume":"40","author":"Schwank S","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.1.79"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.21.20.1479.34476","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.21.20.1479.34476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:30:51Z","timestamp":1761067851000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.21.20.1479.34476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1592\/phco.21.20.1479.34476"],"URL":"https:\/\/doi.org\/10.1592\/phco.21.20.1479.34476","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2001,12]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}