{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T18:32:02Z","timestamp":1761935522626,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3974,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To examine whether the antienterococcal efficacy of a regimen of gentamicin plus vancomycin combined with granulocyte colony\u2010stimulating factor (G\u2010CSF) is enhanced by concurrent therapy with interferon\u2010\u03b3 (IFN\u2010\u03b3).<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> Hospital laboratory.<\/jats:p><jats:p><jats:bold>Intervention.<\/jats:bold> Mice rendered neutropenic by cyclophosphamide were intraperitoneally inoculated with a gentamicin\u2010 and vancomycin\u2010resistant <jats:italic>Enterococcus faecalis<\/jats:italic> isolate.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> Infected animals were randomized into treatment groups that received G\u2010CSF alone or in combination with various dosages of IFN\u2010\u03b3. Additional groups of animals received vancomycin; G\u2010CSF, G\u2010CSF plus vancomycin, IFN\u2010\u03b3, and G\u2010CSF; or vancomycin with both cytokines. Addition of IFN\u2010\u03b3 to G\u2010CSF regimen resulted in no significant change (p&gt;0.05) in survival, compared with treatment with G\u2010CSF alone. Also, the antienterococcal efficacy of antibiotic plus G\u2010CSF was not modified by coadministration of IFN\u2010\u03b3.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> This study suggests that adjunctive application of combined cytokines may not be more beneficial than only G\u2010CSF in combination with an antibiotic to treat multidrug\u2010resistant enterococcal infection.<\/jats:p>","DOI":"10.1592\/phco.21.3.275.34209","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T08:04:29Z","timestamp":1086595469000},"page":"275-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Adjunctive Treatment with Combined Cytokines in a Neutropenic Mouse Model of Multidrug\u2010Resistant <i>Enterococcus faecalis<\/i> Septicemia"],"prefix":"10.1002","volume":"21","author":[{"given":"David 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