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Laboratory tests revealed both rapid hemolysis and severe metabolic acidosis. The patient died the following day. Based on toxicities observed, we suspect that our patient possessed an ethnic polymorphism of the enzyme alcohol dehydrogenase. Further research is required to determine the relationship between the benzyl alcohol metabolic rate and toxicity and genetic polymorphisms of alcohol dehydrogenase in African\u2010Americans.<\/jats:p>","DOI":"10.1592\/phco.21.7.764.34567","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T09:55:05Z","timestamp":1086947705000},"page":"764-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fatal Hemolysis After High\u2010Dose Etoposide: Is Benzyl Alcohol to Blame?"],"prefix":"10.1002","volume":"21","author":[{"given":"Adrienne L.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Haider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill M.","family":"Schachtner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"VanOrden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa C.","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"85","volume-title":"Disposition of toxic drugs and chemicals in man","author":"Baselt R.C.","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.28.367"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/302540"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90315-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(72)90203-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1542\/peds.78.3.541","article-title":"Doxapram and potential benzyl alcohol toxicity: a moratorium on clinical investigation?","volume":"78","author":"Jackson D.","year":"1986","journal-title":"[letter] Pediatrics"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1542\/peds.77.4.507","article-title":"Benzyl alcohol toxicity: impact on neurologic handicaps among surviving very low birth weight infants","volume":"77","author":"Benda G.I.","year":"1986","journal-title":"Pediatrics"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000023"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211253072206"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502900616"},{"key":"e_1_2_1_12_2","first-page":"549","article-title":"Hemolytic effect of benzyl alcohol [letter]","volume":"14","author":"McOrmond P.","year":"1980","journal-title":"Drug Intell Clin Pharm"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.21.7.764.34567","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.21.7.764.34567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:53:13Z","timestamp":1761065593000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.21.7.764.34567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1592\/phco.21.7.764.34567"],"URL":"https:\/\/doi.org\/10.1592\/phco.21.7.764.34567","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}