{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:28:26Z","timestamp":1762003706329,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3852,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>Infections caused by <jats:italic>Cunninghamella bertholletiae<\/jats:italic>, an opportunistic fungal organism, have an extremely high mortality rate. A fatal case of <jats:italic>C. bertholletiae<\/jats:italic> fungal pneumonia occurred in a man who had received an allogeneic bone marrow transplant. Aggressive debridement and high\u2010dose liposomal amphotericin B failed to eradicate the infection. Right lung tissue samples obtained during lobectomy were assayed for amphotericin B concentrations by high\u2010performance liquid chromatography, and minimum inhibitory concentration (MIC) determinations of amphotericin B against <jats:italic>C. bertholletiae<\/jats:italic> were determined by the macrobroth dilution method. The MIC for the isolate of <jats:italic>C. bertholletiae<\/jats:italic> was 4 \u03bcg\/ml. Amphotericin B lung concentrations averaged 9.5 \u03bcg\/ml (range 3.7\u201313.8 \u03bcg\/ml), with a corresponding serum trough concentration of 0.9 \u03bcg\/ml. To our knowledge, this is the first reported case of amphotericin B concentrations measured at the site of infection in a patient with a pulmonary <jats:italic>Cunninghamella<\/jats:italic> infection, together with a corresponding MIC of the organism. The patient's death, which occurred despite aggressive debridement and high amphotericin B lung concentrations, highlights the need for novel strategies to treat infections caused by invasive molds such as <jats:italic>C. bertholletiae<\/jats:italic>.<\/jats:p>","DOI":"10.1592\/phco.21.9.855.34560","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T07:06:28Z","timestamp":1086764788000},"page":"855-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<i>Cunninghamella bertholletiae<\/i> Infection in a Bone Marrow Transplant Patient: Amphotericin Lung Penetration, MIC Determinations, and Review of the Literature"],"prefix":"10.1002","volume":"21","author":[{"given":"Kevin W.","family":"Garey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Pendland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Van Huynh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarqinus H.","family":"Bunch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard M.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Pursell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/83.6.747"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-59"},{"key":"e_1_2_1_4_2","first-page":"282","article-title":"Zygomycosis caused by Cunninghamella bertholletiae: clinical and pathologic aspects","volume":"106","author":"McGinnis M.R.","year":"1982","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199809000-00019"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.2.173"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.6.925"},{"key":"e_1_2_1_8_2","first-page":"311","article-title":"Cunninghamella bertholletiae: an uncommon agent of opportunistic fungal infection. 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