{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:38:52Z","timestamp":1778157532305,"version":"3.51.4"},"reference-count":81,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3852,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p><jats:bold>Purpose.<\/jats:bold> To present a case of chlorpromazine\u2010associated torsades de pointes, review established cases of ventricular arrhythmias associated with chlorpromazine, and describe the proarrhythmic characteristics of this drug.<\/jats:p><jats:p><jats:bold>Data Sources.<\/jats:bold> Articles identified through a search of MEDLINE and IDIS from January 1966\u2013November 2000 and thorough review of the article bibliographies. Patient cases also were identified from a search of the Food and Drug Administration's Adverse Event Reporting System database (November 1997\u2013March 2001). Cases involving intentional overdoses of chlorpromazine were excluded.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> In addition to the case reported herein, 12 cases of documented, chlorpromazine\u2010associated ventricular arrhythmias were identified; five had characteristic features of torsades de pointes. Chlorpromazine delayed repolarization and produced electrocardiographic abnormalities; although, whether chlorpromazine induced torsades de pointes through a mechanism of early afterdepolarizations is unclear. Similar to other instances of drug\u2010induced torsades de pointes, concurrent factors such as electrolyte deficiencies may place the patient at increased risk for arrhythmia.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Chlorpromazine can delay repolarization and produce electrocardiographic abnormalities. These can result infrequently in ventricular arrhythmias and torsades de pointes, particularly in patients with confounding factors.<\/jats:p>","DOI":"10.1592\/phco.21.9.871.34565","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T07:06:28Z","timestamp":1086764788000},"page":"871-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Torsades de Pointes Associated with Chlorpromazine: Case Report and Review of Associated Ventricular Arrhythmias"],"prefix":"10.1002","volume":"21","author":[{"given":"James D.","family":"Hoehns","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas 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