{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:35:14Z","timestamp":1761093314272,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To calculate and compare 24\u2013hour area under the unbound drug concentration\u2010time curves (AUC<jats:sub>0.24<\/jats:sub>) of antimicrobials with dosing recommendations from six commonly used dosing references.<\/jats:p><jats:p><jats:bold>Intervention.<\/jats:bold> Unbound plasma concentration\u2010time profiles of 13 antimicrobial agents (4 penicillins, 3 cephalosporins, 2 carbapenems, aztreonam, 3 fluoroquinolones) were simulated at steady state using a one\u2010compartment open model for a 70\u2013kg adult based on pharmacokinetic parameters obtained from peer\u2010reviewed literature. Simulations were performed at five levels of creatinine clearance (Cl<jats:sub>cr<\/jats:sub>).<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> Differences in AUC<jats:sub>0\u201324<\/jats:sub> for each antimicrobial agent were noted among the six references at each level of Cl<jats:sub>cr<\/jats:sub> as well as within references across the range of Cl<jats:sub>cr<\/jats:sub>. In addition, up to 16\u2013fold and 3\u2013fold ranges in AUC<jats:sub>0\u201324<\/jats:sub> values were observed for \u03b2\u2010lactams and fluoroquinolones, respectively, in one reference based on dosing recommendations at a single level of Cl<jats:sub>cr<\/jats:sub> (due to more than one dose and\/or dosing interval).<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> Clinicians should be aware of differences among common references when selecting dosages of antimicrobial agents, especially for patients with moderate\u2010to\u2010severe renal impairment. 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