{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:38:40Z","timestamp":1791009520805,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To determine whether use of a smaller needle size for subcutaneous injection of enoxaparin would reduce the size of injection\u2010site hematomas and\/or decrease the pain of injection.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> Prospective, randomized trial.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> Community hospital in North Vancouver, British Columbia, Canada.<\/jats:p><jats:p><jats:bold>Patients.<\/jats:bold> One hundred twenty\u2010four patients with unstable angina or non\u2010Q\u2010wave myocardial infarction who were administered enoxaparin for anticoagulation.<\/jats:p><jats:p><jats:bold>Intervention.<\/jats:bold> Each patient was randomly assigned to one of two groups. One group received enoxaparin injections with a 30\u2013gauge, 5\/16\u2013inch insulin syringe, and the other group was injected with a 26\u2013gauge, 3\/8\u2013inch tuberculin syringe.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> Participating nurses used standard measuring tape to determine the largest diameter of each hematoma. Pain was assessed with a 10\u2013unit numeric scale. The two groups did not differ significantly with regard to either the mean size of the largest hematoma\/patient (4.2 cm in the insulin\u2010syringe group vs 3.8 cm in the tuberculin\u2010syringe group, p=0.68) or the mean pain score (0.3 in the insulin\u2010syringe group vs 0.5 in the tuberculin\u2010syringe group, p=0.10).<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Use of a 30\u2013gauge, 5\/16\u2013inch insulin syringe instead of a 26\u2013gauge, 3\/8\u2013inch tuberculin syringe does not significantly reduce either hematoma size or pain of injection. A larger study is required to determine whether needle size affects the frequency of hematoma formation. 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