{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:38:26Z","timestamp":1761100706899,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>The use of low tidal volumes with permissive hypercapnia in patients with acute respiratory distress syndrome may require heavy sedation to allow them to tolerate mechanical ventilation. Administration of methadone for sedation is an alternative to using other opioids, given its longer elimination half\u2010life and incomplete cross\u2010tolerance with other \u03bc\u2010receptor\u2010active opioids. Methadone appears to have a molecular structure similar to that of verapamil, a calcium channel blocker, and may exhibit similar cardiac properties as well. A 43\u2013year\u2010old man with acute respiratory distress syndrome experienced bradycardia while receiving a continuous infusion of methadone for sedation and mechanical ventilation management. This case report demonstrates that caution is warranted when high dosages of methadone are administered because of its potential cardiac effects.<\/jats:p>","DOI":"10.1592\/phco.22.13.1196.33511","type":"journal-article","created":{"date-parts":[[2004,5,28]],"date-time":"2004-05-28T07:26:32Z","timestamp":1085729192000},"page":"1196-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bradycardia Associated with Intravenous Methadone Administered for Sedation in a Patient with Acute Respiratory Distress Syndrome"],"prefix":"10.1002","volume":"22","author":[{"given":"Veena","family":"Karir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(18)30042-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(18)30047-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199422100-00011"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.6.7952641"},{"key":"e_1_2_1_7_2","first-page":"49","article-title":"Tolerance to opioid analgesics: clinical aspects","volume":"21","author":"Portenoy R.K.","year":"1994","journal-title":"Cancer Surv"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1990.tb03441.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931001)72:7<2266::AID-CNCR2820720734>3.0.CO;2-P"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00118-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(83)80101-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90290-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1990.tb03593.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.77"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx950116m"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199513020-00005"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1995.tb04998.x"},{"issue":"3","key":"e_1_2_1_18_2","first-page":"332","article-title":"Ranitidine\u2010induced bradycardia","volume":"83","author":"Khera D.C.","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-3-493"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90978-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292931"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.6.995"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.2.368"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.983"},{"issue":"3","key":"e_1_2_1_25_2","first-page":"135","article-title":"Erythromycin induced cardiovascular toxicity","volume":"52","author":"Fichtenbaum C.J.","year":"1988","journal-title":"Conn Med"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01708583"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1996.tb03650.x"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.22.13.1196.33511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.22.13.1196.33511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:02:51Z","timestamp":1761044571000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.22.13.1196.33511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1592\/phco.22.13.1196.33511"],"URL":"https:\/\/doi.org\/10.1592\/phco.22.13.1196.33511","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2002,9]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}