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The lack of alternative effective therapies for trichomoniasis governed the decision to rechallenge the patient with metronidazole despite a vague history of this reaction on a previous occasion. Six reports of this reaction are found in the literature. The patient was admitted to the hospital 12 hours after taking a single dose of metronidazole. Severe epigastric pain and elevated amylase and lipase concentrations led to the diagnosis of acute pancreatitis, although results of an abdominal ultrasound were unremarkable. The patient made a full recovery. Although this reaction occurs infrequently, this case report illustrates the need to develop additional therapies for treatment of trichomoniasis.<\/jats:p>","DOI":"10.1592\/phco.22.16.1508.33691","type":"journal-article","created":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T10:45:31Z","timestamp":1086086731000},"page":"1508-1510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metronidazole\u2010Induced Pancreatitis in a Patient with Recurrent Vaginal Trichomoniasis"],"prefix":"10.1002","volume":"22","author":[{"given":"David J.","family":"Feola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"361","volume-title":"Principles and practice of infectious diseases","author":"Finegold SM.","year":"2000"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-9-756"},{"issue":"8","key":"e_1_2_1_4_2","first-page":"958","article-title":"Metronidazole\u2010 induced pancreatitis","volume":"84","author":"Celifarco A","year":"1989","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"e_1_2_1_5_2","first-page":"37","article-title":"Acute pancreatitis caused by metronidazole [abstr]","volume":"140","author":"Jongh FE","year":"1996","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-6-891"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.6.1213"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10021"},{"issue":"4","key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/00007435-199904001-00002","article-title":"Estimates of the incidence and prevalence of sexually transmitted diseases in the United States: American social health association panel","volume":"26","author":"Cates WJ.","year":"1999","journal-title":"Sex Transm Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/323034"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/513951"},{"issue":"5","key":"e_1_2_1_12_2","first-page":"397","article-title":"Metronidazole resistant trichomoniasis successfully treated with paromomycin","volume":"73","author":"Coelho DD.","year":"1997","journal-title":"Genitourin Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907223410417"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.22.16.1508.33691","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.22.16.1508.33691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:37:02Z","timestamp":1761064622000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.22.16.1508.33691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1592\/phco.22.16.1508.33691"],"URL":"https:\/\/doi.org\/10.1592\/phco.22.16.1508.33691","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}