{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:40:06Z","timestamp":1761054006242,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3548,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To evaluate the effects of changing volume status on P\u2010wave duration and dispersion in patients with decompensated heart failure.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> Prospective analysis.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> Hospital cardiology unit.<\/jats:p><jats:p><jats:bold>Patients.<\/jats:bold> Twenty\u2010one patients with symptoms of decompensated heart failure who were treated with diuretics on admission.<\/jats:p><jats:p><jats:bold>Intervention.<\/jats:bold> Twelve\u2010lead electrocardiograms were obtained at baseline and after diuresis. Average, minimum, and maximum P\u2010wave duration and P\u2010wave dispersion (minimum minus maximum duration) were determined.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> P\u2010wave duration was measured manually in all 12 leads by using a 0.5\u2010mm\u2010scale precision ruler and magnifying lens. After 40 \u00b1 23 hours of diuresis, 3 \u00b1 1 L of fluid was removed. A significant correlation was found between average P\u2010wave duration and amount of fluid removed (r = \u22120.59, p=0.015). Also, average and maximum P\u2010wave duration were significantly decreased with diuresis (p=0.001 and 0.022, respectively). No other P\u2010wave variables were significantly affected.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Diuresis may attenuate electrophysiologic changes caused by fluid overload.<\/jats:p>","DOI":"10.1592\/phco.22.8.564.33213","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T11:37:53Z","timestamp":1085139473000},"page":"564-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effect of Diuresis on P\u2010Wave Duration and Dispersion"],"prefix":"10.1002","volume":"22","author":[{"given":"Jessica","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Kalus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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