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This was a retrospective chart review of 150 patients who were treated for coronary artery disease in primary care clinics. Appropriate treatment of hypercholesterolemia occurred in 96% of patients referred to a clinical pharmacy specialist, compared with 68% of those followed by primary care providers alone (p&gt;0.0001). Eighty\u2010five percent and 50%, respectively, achieved goal low\u2010density lipoprotein (LDL) values below 105 mg\/dl (p&gt;0.0001). Appropriate therapy with aspirin or other antiplatelet or anticoagulant drugs was prescribed in 97% and 92%, respectively (p=0.146). As appropriate therapy with these agents was high in both groups, the ability to detect a difference between groups was limited. Among patients with an ejection fraction below 40%, appropriate therapy with an angiotensin\u2010converting enzyme inhibitor or acceptable alternative was 89% and 69%, respectively (p&gt;0.05). Twenty\u2010seven cardiac events were documented in the clinical pharmacy group, versus 22 in the primary care group (p=0.475). Despite the relatively high percentage of patients reaching goal LDL in the primary care group, referral to clinical pharmacy specialists resulted in statistically significant increases in the number of patients appropriately treated for hypercholesterolemia and achieving goal LDL.<\/jats:p>","DOI":"10.1592\/phco.22.9.738.34061","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T04:48:04Z","timestamp":1086583684000},"page":"738-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Optimizing Drug Therapy in Patients with Cardiovascular Disease: The Impact of Pharmacist\u2010Managed Pharmacotherapy Clinics in a Primary Care 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