{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T18:31:39Z","timestamp":1761935499033,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3517,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>A 58\u2010year\u2010old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatient setting. Within the first 3 days of administering the spray, he developed wheezing, coughing, and significant shortness of breath, which required hospitalization. The patient was hospitalized for 48 hours and discharged with a diagnosis of asthma exacerbation probably related to administration of nicotine nasal spray. Prudent administration of nicotine nasal spray is recommended in patients with underlying respiratory disease. Patients should be counseled on the potential adverse effects of treatment and proper administration techniques in order to minimize these effects.<\/jats:p>","DOI":"10.1592\/phco.22.9.779.34069","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T04:48:04Z","timestamp":1086583684000},"page":"779-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Asthma Exacerbation After Administration of Nicotine Nasal Spray for Smoking Cessation"],"prefix":"10.1002","volume":"22","author":[{"given":"Mary T.","family":"Roth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Westman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"volume-title":"Nicotrol NS (nicotine nasal spray) package insert","year":"1996","author":"McNeil Consumer Products Co.","key":"e_1_2_1_2_2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91403-U"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1001\/archinte.1994.00420220059007","article-title":"Effect of nicotine nasal spray on smoking cessation: a randomized, placebo\u2010controlled, double\u2010blind study","volume":"154","author":"Hjalmarson A.","year":"1994","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1995.901216719.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63642-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195114966.001.0001"},{"volume-title":"Clinical epidemiology. A basic science for clinical medicine","year":"1991","author":"Sackett D.L.","key":"e_1_2_1_8_2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.22.9.779.34069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.22.9.779.34069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:37:44Z","timestamp":1761053864000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.22.9.779.34069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1592\/phco.22.9.779.34069"],"URL":"https:\/\/doi.org\/10.1592\/phco.22.9.779.34069","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2002,6]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}