{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:46:24Z","timestamp":1787942784887,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":3517,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>A 48\u2010year\u2010old man, hospitalized after experiencing subarachnoid hemorrhage secondary to a basilar aneurysm, received vancomycin for methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> sepsis. He developed neutropenia 16 days after the start of vancomycin therapy, and his white blood cell count decreased to a nadir of 1200 cells\/mm<jats:sup>3<\/jats:sup>. Vancomycin was discontinued, and granulocyte\u2010colony stimulating factor (G\u2010CSF) therapy was begun. The patient was rechallenged with a single dose of vancomycin 1 g in preparation for intraarterial aneurysm coiling. His white blood cell count dropped to 600 cells\/mm<jats:sup>3<\/jats:sup> but returned to normal with continued G\u2010CSF therapy. A diagnosis of vancomycin\u2010induced neutropenia was considered. Subsequent testing by granulocyte agglutination and granulocyte immunofluorescence assays revealed that his serum was positive for an antigranulocyte antibody. A test for HLA antibody reactivity was negative. Monoclonal antibody immobilization of granulocyte antigens assay failed to determine the antigen specificity of his granulocyte antibody.<\/jats:p>","DOI":"10.1592\/phco.22.9.783.34059","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T04:48:04Z","timestamp":1086583684000},"page":"783-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Vancomycin\u2010Induced Neutropenia in a Patient Positive for an Antineutrophil Antibody"],"prefix":"10.1002","volume":"22","author":[{"given":"Michael D.","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"428","article-title":"Clinical use of vancomycin","author":"Dangerfield H.G.","year":"1960","journal-title":"Antimicrob Agents Ann"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.1.138"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(05)80002-7"},{"issue":"10","key":"e_1_2_1_5_2","first-page":"783","article-title":"Vancomycin\u2010induced neutropenia during treatment of osteomyelitis in an outpatient","volume":"20","author":"Henry K.","year":"1986","journal-title":"Drug Intell Clin Pharm"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.3.240.30912"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19051"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.4.575"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198209000-00029"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198110000-00028"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90407-9"},{"key":"e_1_2_1_12_2","first-page":"41","article-title":"Vancomycin\u2010induced neutropenia associated with anti\u2010granulocyte antibodies","volume":"6","author":"Domen R.E.","year":"1990","journal-title":"Immuno-hematology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91710-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90037-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700780"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1177\/106002809703101109","article-title":"Agranulocytosis induced by vancomycin or ticarcillin\/clavulanate","volume":"31","author":"Mandl D.L.","year":"1997","journal-title":"Ann Pharmacother"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/106002809402800607","article-title":"Vancomycin\u2010induced neutropenia during treatment of endocarditis in a pediatric patient","volume":"28","author":"Shinohara Y.T.","year":"1994","journal-title":"Ann Pharmacother"},{"key":"e_1_2_1_18_2","first-page":"39","article-title":"Vancomycin\u2010induced neutropenia","volume":"132","author":"Mackett R.L.","year":"1985","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90915-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37997454028.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39050527.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.4.844"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.22.9.783.34059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.22.9.783.34059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:37:45Z","timestamp":1761053865000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.22.9.783.34059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1592\/phco.22.9.783.34059"],"URL":"https:\/\/doi.org\/10.1592\/phco.22.9.783.34059","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]},"assertion":[{"value":"2012-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}