{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:43:12Z","timestamp":1785386592144,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":3059,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>\n                    A 23\u2010year\u2010old man was brought to the emergency department after eating four boxes of brodifacoum\u2010containing rodenticide over a 4\u2010day interval and pieces from approximately two bottles of glass over the previous 2 weeks. He was asymptomatic but his prothrombin time was markedly elevated with an international normalized ratio (INR) of 37.8. A plain abdominal film showed diffuse radiopaque foreign bodies, presumably glass, in the large and distal small intestines. Treatment for ingested glass consisted of stool softeners and bulk\u2010forming laxatives. The patient developed mild gingival bleeding and received fresh frozen plasma (FFP) infusions and vitamin K\n                    <jats:sub>1<\/jats:sub>\n                    orally. At a vitamin K\n                    <jats:sub>1<\/jats:sub>\n                    dosage of 300 mg\/day, the INR corrected to less than 2.0 and the patient was discharged taking that dosage. He returned 26 days later with hematuria and flank pain, and his INR was 189. He was administered FFP and packed red blood cells, and his vitamin K\n                    <jats:sub>1<\/jats:sub>\n                    dosage was increased to 800 mg\/day; his INR returned to baseline. Compliance with taking the vitamin K1, which required ingestion of 60\u2013160 tablets\/day, was a serious problem, requiring numerous follow\u2010up calls and visits to the patient at home and work. At 5\u2010month follow he was doing well. Compliance with large daily doses of vitamin K\n                    <jats:sub>1<\/jats:sub>\n                    for treatment of \u201csuperwarfarin\u201d ingestion may be poor because of the duration of treatment and large number of pills required. A more concentrated formulation may be advantageous for management of patients with brodifacoum poisoning.\n                  <\/jats:p>","DOI":"10.1592\/phco.23.10.1186.32755","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T05:48:28Z","timestamp":1084513708000},"page":"1186-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Superwarfarin and Glass Ingestion with Prolonged Coagulopathy Requiring High\u2010Dose Vitamin K\n                    <sub>1<\/sub>\n                    Therapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Ben T.","family":"Tsutaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey M.","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent R.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9702500622"},{"key":"e_1_2_1_3_2","first-page":"554","article-title":"Not all rats have four legs. Superwarfarin poisoning","volume":"55","author":"Mack RB","year":"1994","journal-title":"N C Med J"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.4.1301"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)80900-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/20.1.25"},{"key":"e_1_2_1_7_2","first-page":"568","article-title":"Elimination kinetics of brodifacoum and serum vitamin K1 concentrations in long\u2010acting anticoagulant (LAA) overdose (OD) [abstr]","volume":"34","author":"Bruno GR","year":"1996","journal-title":"J Toxicol Clin Toxicol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.108317"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.17.1929"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410160099010"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1975.01360180064014"},{"key":"e_1_2_1_12_2","first-page":"193","article-title":"Endoscopic removal of a large intragastric foreign body with an overtube: a case report","volume":"54","author":"Sheu BS","year":"1994","journal-title":"Chin Med J"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.23.10.1186.32755","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.23.10.1186.32755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:55:28Z","timestamp":1761065728000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.23.10.1186.32755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1592\/phco.23.10.1186.32755"],"URL":"https:\/\/doi.org\/10.1592\/phco.23.10.1186.32755","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}