{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:34:00Z","timestamp":1775237640393,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":3271,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2003,2]]},"abstract":"\n Study Objective<\/jats:bold>\n . To determine the effects of 4\u2010aminopyridine (4\u2010AP) on heart rate and PR, QT, and QTc intervals in patients with longstanding spinal cord injury (SCI).\n <\/jats:p>\n \n Design<\/jats:bold>\n . Randomized, active\u2010treatment\u2014controlled, dose level\u2014blinded study with allocation concealed.\n <\/jats:p>\n \n Setting<\/jats:bold>\n . University\u2010affiliated, tertiary care medical center.\n <\/jats:p>\n \n Patients<\/jats:bold>\n . Sixty otherwise healthy male and female outpatients with traumatic SCI of more than 1 year's duration.\n <\/jats:p>\n \n Intervention<\/jats:bold>\n . Oral administration and dose titration to tolerance of an immediate\u2010release formulation of 4\u2010AP.\n <\/jats:p>\n \n Measurements and Main Results<\/jats:bold>\n . The PR interval, heart rate, QT interval, and QTc interval obtained from standard 12\u2010lead electrocardiograms (ECGs) at baseline (before administration of 4\u2010AP) and after 1 month of treatment were compared. The QTc intervals were derived by using Bazett's formula (equation) incorporated into standard computerized analyses of 12\u2010lead ECG printouts. The paired\n t<\/jats:italic>\n test was performed to test for the significance of differences between means and variances. No statistically significant differences were noted in heart rate or between ECG time intervals measured at baseline and after 1 month of treatment with 4\u2010AP among all patients with SCI or between subgroups stratified by injury level (tetraplegia, paraplegia) or sex.\n <\/jats:p>\n \n Conclusion<\/jats:bold>\n . During the 1\u2010month period that 4\u2010AP was administered, the heart rate and PR, QT, and QTc intervals all remained unchanged and stayed well within normal range in comparison to literature\u2010derived control values. 4\u2010Aminopyridine does not appear to influence the length of cardiac time intervals or heart rate and, hence, is unlikely to cause potentially life\u2010threatening ventricular dysrrhythmias when administered long\u2010term and taken orally in dosages of up to 30 mg\/day. Specifically, cardiac repolarization (QTc interval) is unaffected in patients with SCI who continuously receive 4\u2010AP for up to 1 month.\n <\/jats:p>","DOI":"10.1592\/phco.23.2.133.32089","type":"journal-article","created":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T07:16:40Z","timestamp":1084259800000},"page":"133-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of 4\u2010Aminopyridine on Cardiac Repolarization, PR Interval, and Heart Rate in Patients with Spinal Cord Injury"],"prefix":"10.1002","volume":"23","author":[{"given":"Wakana C.","family":"Isoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack L.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200111000-00010"},{"key":"e_1_2_1_3_2","first-page":"75","volume-title":"Advances in neurology","author":"Bunge RP","year":"1993"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02309623"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.9.713.31540"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700022009233"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922007912"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.e24"},{"key":"e_1_2_1_9_2","volume-title":"International standards for neurological and functional classification of spinal cord injury","author":"American Spinal Cord Injury Association\u2010International Medical Society of Paraplegia.","year":"1996"},{"key":"e_1_2_1_10_2","first-page":"156","volume-title":"Geigy scientific tables: heart and circulation","author":"Lentner C.","year":"1990"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.23.2.133.32089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:55:03Z","timestamp":1761065703000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.23.2.133.32089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1592\/phco.23.2.133.32089"],"URL":"https:\/\/doi.org\/10.1592\/phco.23.2.133.32089","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}