{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:32:37Z","timestamp":1763015557347,"version":"build-2065373602"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":3151,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>\n                    <jats:bold>Study Objectives.<\/jats:bold>\n                    To determine the prevalence of osteoporosis as assessed by peripheral bone mineral density (BMD) in women living in a nursing home, to determine how many women with low BMD had received a diagnosis of osteoporosis, to assess the prevalence of vitamin D deficiency, and to seek reasons for vitamin D deficiency.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design.<\/jats:bold>\n                    Measurement of calcaneal BMD and serum 25\u2010hydroxyvitamin D.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting.<\/jats:bold>\n                    Skilled nursing facility.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients.<\/jats:bold>\n                    Forty\u2010nine women aged 68\u2013100 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Measurements and Main Results.<\/jats:bold>\n                    Bilateral calcaneal BMD was measured by dual\u2010energy x\u2010ray absorptiometry and serum 25\u2010hydroxyvitamin D by radioimmunoassay. Medical records were reviewed to assess osteoporosis risk factors, previous documentation of osteoporosis or malabsorption, and supplemental vitamin D intake. Fifty\u2010nine percent of the 39 women with calcaneal BMD measurements (95% confidence interval [CI] 44\u201374%) exhibited calcaneal osteoporosis (T score &lt; \u22122.5). Sixty percent (95% CI 46\u201374%) had 25\u2010hydroxyvitamin D levels of 20 ng\/ml or less, which is associated with secondary hyperparathyroidism; only 4% of women had levels above 30 ng\/ml, recently recommended as optimal. Vitamin D status was suboptimal even in most women taking multivitamins. Osteoporosis was documented in the records of 17% of 23 women with calcaneal osteoporosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    Osteoporosis was prevalent but poorly documented in women living in the nursing home. Peripheral BMD measurements have the potential to improve the recognition and management of osteoporosis in women in long\u2010term care facilities. The high prevalence of vitamin D deficiency, even in those taking multivitamins, indicates that practical new approaches for vitamin D repletion in this population are urgently needed.\n                  <\/jats:p>","DOI":"10.1592\/phco.23.6.702.32182","type":"journal-article","created":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T09:57:16Z","timestamp":1084269436000},"page":"702-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Fracture Risks for Women in Long\u2010Term Care: High Prevalence of Calcaneal Osteoporosis and Hypovitaminosis D"],"prefix":"10.1002","volume":"23","author":[{"given":"Mary E.","family":"Elliott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil C.","family":"Binkley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Carnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Behlke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Ahmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara A.","family":"Kieser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"685","article-title":"Diagnosis and treatment of osteoporosis in long\u2010term care facilities","volume":"13","author":"Baran RW","year":"1998","journal-title":"Consult Pharm"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02352254"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555097"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/25.5.381"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-198902000-00002"},{"issue":"1","key":"e_1_2_1_7_2","first-page":"M335","article-title":"Hip fractures and other osteoporosis\u2010related sequelae in elderly male nursing home residents [abstr]","volume":"14","author":"Sergev O","year":"1999","journal-title":"J Bone Min Res"},{"issue":"1","key":"e_1_2_1_8_2","first-page":"WG07","article-title":"Correction of high incidence of nonskeletal risk factors for fractures is associated with decreased hip fracture risk in nursing homes: a cross\u2010sectional survey [abstr]","volume":"14","author":"Geusens P","year":"1999","journal-title":"J Bone Min Res"},{"issue":"4","key":"e_1_2_1_9_2","first-page":"1","article-title":"Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost\u2010effectiveness analysis","volume":"8","author":"National Osteoporosis Foundation.","year":"1998","journal-title":"Osteoporos Int"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08761-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321202"},{"issue":"1","key":"e_1_2_1_13_2","first-page":"S2","article-title":"Prevention of osteoporotic hip fracture: global versus high\u2010risk strategies","volume":"8","author":"Barrett\u2010Connor E","year":"1998","journal-title":"Osteoporos Int"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00115-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.701521.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb06452.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.suppl_4.1159S"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1129"},{"issue":"4","key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"1165S","DOI":"10.1093\/jn\/126.suppl_4.1165S","article-title":"Calcium and vitamin D nutritional needs of elderly women","volume":"126","author":"Dawson\u2010Hughes B","year":"1996","journal-title":"J Nutr"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7171.1466"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb07059.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.3.638S"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb06950.x"},{"volume-title":"PIXI bone densitometer operator's manual","year":"1999","author":"GE Lunar Corporation.","key":"e_1_2_1_25_2"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.8.972"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.22.2815"},{"volume-title":"Biostatistics: a methodology for the health sciences","year":"1993","author":"Fisher LD","key":"e_1_2_1_28_2"},{"volume-title":"Statistics with applications to the biological and health sciences","year":"1985","author":"Remington RD","key":"e_1_2_1_29_2"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.4125"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03560-1"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.5.825"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.2.342"},{"volume-title":"Dietary reference intakes: calcium, phosphorus, magnesium, vitamin D, and fluoride","year":"1997","author":"Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Institute of Medicine.","key":"e_1_2_1_35_2"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.8.1303"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070059"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.73.865.10721317"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6753.638"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070055"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1331\/108658002763538134"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200211000-00011"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298717"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272305"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00022725"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.11.3817"},{"key":"e_1_2_1_47_2","first-page":"69","article-title":"Differences in vitamin D status between countries in young adults and the elderly","volume":"93","author":"McKenna MJ","year":"1992","journal-title":"Am J Nutr"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/46.6.1005"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb116014.x"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.16.1505"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803193381201"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.3086"},{"issue":"1","key":"e_1_2_1_53_2","first-page":"1038","article-title":"Vitamin D dose\u2010response relationships [abstr]","volume":"16","author":"Heaney RP","year":"2001","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.288"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-10-200205210-00009"},{"issue":"1","key":"e_1_2_1_56_2","first-page":"SA292","article-title":"Cost of hip fractures and estimate of treatment cost effectiveness in Wisconsin nursing home residents [abstr]","volume":"16","author":"Elliott ME","year":"2001","journal-title":"J Bone Min Res"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:2:3:343"},{"issue":"2","key":"e_1_2_1_58_2","first-page":"S58","article-title":"Revision of T\u2010score BMD diagnostic thresholds [abstr]","volume":"11","author":"Joint National Osteoporosis Foundation\/International Society for Clinical Densitometry\/American Society for Bone and Mineral Research Committee on Simplification of the Bone and Mineral Society Reporting.","year":"2000","journal-title":"Osteoporos Int"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.23.6.702.32182","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.23.6.702.32182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:32:26Z","timestamp":1761067946000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.23.6.702.32182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1592\/phco.23.6.702.32182"],"URL":"https:\/\/doi.org\/10.1592\/phco.23.6.702.32182","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2003,6]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}