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Without adequate prophylaxis, patients undergoing major orthopedic surgery are at high risk of developing VTE. Prophylaxis with either unfractionated heparin or warfarin not only substantially reduces the risk of VTE after orthopedic surgery, but also is more cost\u2010effective than no prophylaxis. Low\u2010molecular\u2010weight heparins (LMWHs) have been shown to be superior to unfractionated heparin or warfarin, and despite the fact that they are more expensive, they are cost\u2010effective. Large\u2010scale clinical trials have shown that fondaparinux further reduces the likelihood of VTE complications after major orthopedic surgery. A review of the pharmacoeconomic evaluations of fondaparinux leads to the conclusion that fondaparinux is a cost\u2010effective alternative to LMWHs in VTE prophylaxis.<\/jats:p>","DOI":"10.1592\/phco.24.10.95s.36123","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T11:04:13Z","timestamp":1090494253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pharmacoeconomics of Thrombosis Management"],"prefix":"10.1002","volume":"24","author":[{"given":"David","family":"Hawkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"issue":"1","key":"e_1_2_1_2_2","first-page":"S1","article-title":"Sixth ACCP consensus conference on antithrombotic therapy","volume":"119","author":"American College of Chest 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