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In terms of acute coronary syndromes, the American College of Cardiology and the American Heart Association (ACC\u2010AHA) have developed extensive guidelines to assist the practitioner in the appropriate use of drugs including antiischemic, anticoagulant, and antiplatelet agents. Clopidogrel, an adenosine 5\u2032\u2010diphosphate antagonist, is one such drug. Unfortunately, consensus guidelines are limited by the design of the clinical trials they reference. Clopidogrel trials have examined various outcomes in patients for a limited time frame, making longer term use of the drug difficult to justify. An ongoing study, estimated to be completed in 2005, is evaluating the long\u2010term use of clopidogrel in high\u2010risk patients. Aspirin, however, has become a lifelong therapy for many patients, based on clinical trials and medical experience. Patient\u2010specific risk factors, the drugs' safety profiles, and costs, in addition to the ACC\u2010AHA guidelines, must all be considered by clinicians when selecting the appropriate agent and its duration of use.<\/jats:p>","DOI":"10.1592\/phco.24.11.1037.36135","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T06:20:35Z","timestamp":1090563635000},"page":"1037-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Clopidogrel in Unstable Angina and Non\u2014ST\u2010Segment Elevation Myocardial Infarction: From Literature and Guidelines to Practice"],"prefix":"10.1002","volume":"24","author":[{"given":"Jessica L.","family":"Kerr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Oppelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall C.","family":"Rowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960190506"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2003.180"},{"key":"e_1_2_1_4_2","first-page":"261","volume-title":"Thrombosis and hemorrhage","author":"Kroll M.","year":"1998"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.123469"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.3.361"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960231103"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1206"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810273191701"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05701-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00428-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","article-title":"Collaborative overview of randomized trials of antiplatelet therapy. 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