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Infections with non\u2010<jats:italic>albicans Candida<\/jats:italic> sp are becoming more frequent, and resistance among these isolates is concerning. <jats:italic>Candida kefyr<\/jats:italic> is an uncommonly documented fungal pathogen. We report two cases of infection resulting from <jats:italic>C. kefyr<\/jats:italic> in our institution. The two patients had underlying disease states and drug therapies that increased the likelihood of developing an immunocompromised state. The <jats:italic>C. kefyr<\/jats:italic> isolates obtained from both patients were susceptible to amphotericin B, fluconazole, and itraconazole. 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