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Nesiritide may be beneficial in combination with diuretics because it reduces activity of the renin\u2010angiotensin\u2010aldosterone system. It is unclear how potent nesiritide is as a diuretic. Patients exhibit wide variability in clinical response from the diuretic effects of the drug. Two patients were given a combination of nesiritide and diuretics as initial treatment of right\u2010sided heart failure; both experienced significant diuresis and weight loss. Further literature is needed to clarify the role of nesiritide in the treatment of right\u2010sided heart failure.<\/jats:p>","DOI":"10.1592\/phco.24.13.1236.38092","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T10:09:29Z","timestamp":1092218969000},"page":"1236-1240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nesiritide for Treatment of Heart Failure Due to Right Ventricular Dysfunction"],"prefix":"10.1002","volume":"24","author":[{"given":"Randall P.","family":"Sharp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Mowdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riaz","family":"Sirajuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"issue":"7","key":"e_1_2_1_2_2","first-page":"929","article-title":"BNP in decompensated heart failure: diagnostic, prognostic and therapeutic potential","volume":"2","author":"Burger MR","year":"2001","journal-title":"Curr Opin Invest Drugs"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.12.1266.32705"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/107424840200700308"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.8.865"},{"key":"e_1_2_1_6_2","unstructured":"Scios Inc.Natrecor (nesiritide) package insert. 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