{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:13:36Z","timestamp":1770563616260,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":2602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>A 43\u2010year\u2010old man with chronic back and shoulder pain was treated with hydrocodone. He began taking excessive amounts of the drug, so his physicians stopped prescribing it. The patient then obtained the muscle relaxant carisoprodol on his own from several sources. He was consuming up to 30 or more tablets\/day (\u2265 10,500 mg\/day) for several weeks, then abruptly stopped taking the drug. Within 48 hours he developed anxiety, tremors, muscle twitching, insomnia, auditory and visual hallucinations, and bizarre behavior. The symptoms intensified and peaked on the fourth day after carisoprodol cessation. The patient required brief treatment with olanzapine and tapering dosages of lorazepam while the symptoms gradually resolved. To our knowledge, this is the first documented case of a withdrawal syndrome with carisoprodol. The symptoms most likely resulted because of accumulation of meprobamate, the active metabolite of carisoprodol in humans. Clinicians prescribing carisoprodol should be aware of the possibility for abuse or addiction. Further, we recommend that carisoprodol be designated a controlled substance at the federal level.<\/jats:p>","DOI":"10.1592\/phco.24.17.1804.52333","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T15:10:40Z","timestamp":1100531440000},"page":"1804-1806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Carisoprodol Withdrawal Syndrome"],"prefix":"10.1002","volume":"24","author":[{"given":"Roy R.","family":"Reeves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Beddingfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199808000-00004"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199307000-00006"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952997809007027"},{"key":"e_1_2_1_5_2","first-page":"1223","article-title":"Abuse of skeletal muscle relaxants","volume":"44","author":"Elder NC.","year":"1991","journal-title":"Am Fam Physician"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.2.4.429"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1993.tb03462.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440050051013"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952999309002671"},{"key":"e_1_2_1_10_2","first-page":"723","article-title":"Carisoprodol: a drug of continuing abuse","volume":"97","author":"Reeves RR","year":"1997","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0022-3565(25)39319-5","article-title":"Lorazepam and meprobamate dose effects in humans: behavioral effects and abuse liability","volume":"243","author":"Roache JD","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200105000-00015"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-3565(25)26382-0","article-title":"The metabolic fate of carisoprodol in the dog","volume":"138","author":"Douglas JF","year":"1962","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199408000-00001"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS10259J"},{"key":"e_1_2_1_16_2","first-page":"281","article-title":"Et tilfaede af akut karisoprodol forgiftning","volume":"138","author":"Brandslund I","year":"1976","journal-title":"Ugeskr Laeg"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195806122582401"},{"key":"e_1_2_1_18_2","first-page":"1961","article-title":"Further controlled studies of meprobamate","volume":"10","author":"Bulla JD","year":"1959","journal-title":"Am Pract Dig Treat"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1300\/J069v18n02_05"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.24.17.1804.52333","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.24.17.1804.52333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:52:48Z","timestamp":1761054768000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.24.17.1804.52333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1592\/phco.24.17.1804.52333"],"URL":"https:\/\/doi.org\/10.1592\/phco.24.17.1804.52333","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}