{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:54:04Z","timestamp":1761162844120,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":2906,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>\n                    <jats:bold>Study Objective.<\/jats:bold>\n                    To estimate blood pressure control and identify treatment variables predicting control in treatment\u2010compliant, hypertensive, male veterans.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting.<\/jats:bold>\n                    Outpatient clinic of a Veterans Affairs medical center.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design.<\/jats:bold>\n                    Retrospective review of computerized patient records over a 12\u2010month period for demographics, comorbidities, patient\u2010specific blood pressure goals, blood pressure history, antihypertensive therapy, and refill history.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients.<\/jats:bold>\n                    Two hundred fifty hypertensive men aged 39\u201390 years whose antihypertensive regimen remained unchanged over 12 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Measurements and Main Results.<\/jats:bold>\n                    The proportion of patients with blood pressures below 160\/90 mm Hg was 86%; only 34.8% had pressures below 140\/90 mm Hg. Blood pressure control was less common with advancing age (42.1%, 33.7%, and 29.4% for patients aged &lt; 60, 60\u201375, and &gt; 75 yrs, respectively, p=0.057 for trend). Treatment intensity was highest in obese men, those aged 60\u201375 years, and those with a history of chronic heart failure or angina, and lowest in men older than 75 years or with a history of stroke. Blood pressure control was independently associated with therapy with \u03b2\u2010blockers (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.5\u201310.2, p=0.005), loop diuretics (OR 4.3, 95% CI 1.6\u201312.1, p=0.005), angiotensin\u2010converting enzyme inhibitors (OR 3.1, 95% CI 1.2\u20138.2, p=0.025), and long\u2010term simvastatin therapy (OR 3.7, 95% CI 1.9\u20137.4, p=0.0001), and with a diagnosis of coronary artery disease (OR 3.2, 95% CI 1.35\u20137.69, p=0.009). The relationship between simvastatin therapy and blood pressure control persisted after controlling for the higher treatment intensity in patients taking the drug. Factors predicting poor control included a history of stroke (OR for control 0.36, 95% CI 0.19\u20130.69, p=0.002), age over 75 years (OR 0.43, 95% CI 0.18\u20130.98, p=0.046), highest low\u2010density lipoprotein tertile (OR 0.37, 95% CI 0.17\u20130.80, p=0.013), highest body mass index tertile (OR 0.46, 95% CI 0.21\u20131.00, p=0.05), and therapy with two or fewer antihypertensives (OR 0.14, 95% CI 0.04\u20130.61, p=0.009).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    In a compliant veteran population, control of blood pressure appeared inadequate but was significantly more likely in those receiving at least three antihypertensive agents. Long\u2010term therapy with simvastatin was independently associated with increased odds of control.\n                  <\/jats:p>","DOI":"10.1592\/phco.24.2.179.33136","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T05:30:14Z","timestamp":1085117414000},"page":"179-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Blood Pressure Control and Factors Predicting Control in a Treatment\u2010Compliant Male Veteran Population"],"prefix":"10.1002","volume":"24","author":[{"given":"Marcel D.","family":"Bizien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra G.","family":"Jue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Panning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Cusack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teri","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archinte.1993.00410020010002","article-title":"The fifth report of the National Committee on Detection, Evaluation, and Treatment of High Blood Pressure","volume":"153","author":"National Committee on Detection, Evaluation, and Treatment of High Blood Pressure.","year":"1993","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91783-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.3.305"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010273"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.11.1725"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.4.3.415"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200004000-00006"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00132-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198808000-00007"},{"key":"e_1_2_1_11_2","first-page":"157","volume-title":"Pharmacotherapy: a pathophysiological approach","author":"Carter B.L.","year":"2002"},{"key":"e_1_2_1_12_2","unstructured":"National Heart Lung and Blood Institute.CVD\u2010related HP 2010 objectives. 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