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A 76\u2010year\u2010old Caucasian man developed clubbing of the fingernails and discoloration of both the fingernails and toenails after 27 days of treatment with the angiotensin II receptor blocker (ARB) losartan 50 mg\/day. Even though this therapy was switched to valsartan, the nail changes persisted for another 6 months. The patient's therapy then was changed to captopril, and the changes gradually subsided over 17 months. An extensive literature search revealed no reports of this effect in association with ARBs. However, one manufacturer had received spontaneous reports. Despite careful consideration of other possible causes of the patient's symptoms, the temporal association with the start and discontinuation of ARB therapy suggests a possible drug\u2010related adverse event.<\/jats:p>","DOI":"10.1592\/phco.24.5.546.33345","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T04:52:13Z","timestamp":1085460733000},"page":"546-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fingernail Clubbing and Chromonychia Associated with the Use of Angiotensin II Receptor Blockers"],"prefix":"10.1002","volume":"24","author":[{"given":"Kathleen A.","family":"Packard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Arouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Hilleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Gannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00042310-200016010-00005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02134-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91843-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.3.1.57"},{"key":"e_1_2_1_7_2","first-page":"515","volume-title":"Drug facts and comparisons","author":"Hebel SK","year":"2003"},{"key":"e_1_2_1_8_2","first-page":"153","volume-title":"Basic and clinical pharmacology","author":"Benowitz NL.","year":"1998"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91132-9"},{"issue":"4","key":"e_1_2_1_10_2","first-page":"187","article-title":"Cyanosis due to pulmonary arteriovenous malformation","volume":"38","author":"Meredith JT.","year":"1988","journal-title":"Am Fam Physician"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6194.825"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000403346"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10193"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(79)90055-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.2.117"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000647"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1998.2125"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.56.662.862"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.24.5.546.33345","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.24.5.546.33345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:17:02Z","timestamp":1761052622000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.24.5.546.33345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1592\/phco.24.5.546.33345"],"URL":"https:\/\/doi.org\/10.1592\/phco.24.5.546.33345","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}