{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:12:41Z","timestamp":1761163961307,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":2755,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2004,7]]},"abstract":"\n Study Objective.<\/jats:bold>\n To determine the effects of drugs on levels of carbohydrate\u2010deficient transferrin (CDT), using the %CDT test, a new alcohol biomarker, in patients receiving drug therapy for chronic medical conditions such as diabetes mellitus, hypertension, and lipid disorders.\n <\/jats:p>\n \n Design.<\/jats:bold>\n Regression analysis of transformed data.\n <\/jats:p>\n \n Setting.<\/jats:bold>\n Eight primary care clinics in central Wisconsin.\n <\/jats:p>\n \n Patients.<\/jats:bold>\n Seven hundred ninety\u2010nine primary care patients who were prescribed drug therapy for a variety of chronic illnesses such as diabetes, hypertension, and lipid disorders.\n <\/jats:p>\n \n Measurements and Main Results.<\/jats:bold>\n The %CDT level, 30\u2010day history of alcohol consumption, symptoms of alcohol abuse or dependence, health status, and prescribed drugs were determined for each patient. All prescribed drugs that were taken by the patients in the last month were determined by self\u2010report, medical records, or pharmacy records. Of the 799 patients, 89 were receiving drug therapy for diabetes, 299 for hypertension, 209 for both diabetes and hypertension, and 202 for medical conditions other than diabetes or hypertension. A regression analysis was performed after the data were transformed. Alcohol consumption, sex, age, tobacco use, and 20 drug classes were entered into the model. Factors associated with increased %CDT levels were alcohol consumption, female sex, and bupropion use. Two additional drug classes, the angiotensin II receptor blockers and the tricyclic antidepressants, were associated with lower %CDT levels. The effects of bupropion and tricyclic antidepressants on %CDT levels, however, appear to be confounded by alcohol intake.\n <\/jats:p>\n \n Conclusion.<\/jats:bold>\n This study suggests that only one of 20 drug classes\u2014the angiotensin II receptor blockers\u2014affected %CDT levels in our primary care sample. Additional research with larger samples is needed to focus on the effects of individual drugs used in general clinical settings on %CDT levels.\n <\/jats:p>","DOI":"10.1592\/phco.24.9.831.36105","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T10:46:31Z","timestamp":1090493191000},"page":"831-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential Drug Interactions with the Percent Carbohydrate\u2010Deficient Transferrin (%CDT) Test, a New Alcohol Biomarker"],"prefix":"10.1002","volume":"24","author":[{"given":"Marlon P.","family":"Mundt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie K.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"429","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Fleming M.","year":"2001"},{"issue":"1","key":"e_1_2_1_3_2","first-page":"40","article-title":"Alcohol and medication interactions","volume":"23","author":"Weathermon R.","year":"1999","journal-title":"Alcohol Res Health"},{"volume-title":"Tenth special report to the U.S. Congress on alcohol and health","year":"2000","author":"National Institute on Alcohol Abuse and Alcoholism.","key":"e_1_2_1_4_2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1046\/j.1359-6357.2003.00587.x"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_2","DOI":"10.1046\/j.1365-2362.1999.00556.x"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1111\/j.1530-0277.1995.tb01021.x"},{"unstructured":"Department of Health and Human Services.42 CFR part 410: medical program negotiated rule making: coverage and administrative policies for clinical diagnostic laboratory services final rule. 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