{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T09:33:14Z","timestamp":1792315994303,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":2451,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>\n                    <jats:bold>Study Objective.<\/jats:bold>\n                    To estimate the costs of hospitalization for neutropenia among chemotherapy\u2010treated patients with newly diagnosed non\u2010Hodgkin's lymphoma and to assess baseline patient factors associated with these costs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design.<\/jats:bold>\n                    Retrospective cohort study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Data Source.<\/jats:bold>\n                    Linked Surveillance, Epidemiology, and End Results Program\u2013Healthcare Cost and Utilization Project databases for Iowa from 1993\u20131998.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients.<\/jats:bold>\n                    Patients with newly diagnosed non\u2010Hodgkin's lymphoma who received all inpatient care at Iowa hospitals during their first course of chemotherapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Measurements and Main Results.<\/jats:bold>\n                    Neutropenia\u2010related hospitalization costs were estimated from discharge abstracts found within the earliest of the following: 6 months after the diagnosis month, the date of bone marrow transplantation, or date of death. We performed univariate tests of differences in neutropenia\u2010related hospitalization costs in all patients in the sample, as well as tests for neutropenia\u2010related hospitalization costs, length\u2010of\u2010stay, and cost\/inpatient day for patients with at least one hospitalization for neutropenia. We modeled total inpatient charges over the period for patients with at least one neutropenia\u2010related hospitalization (multiple regression). A total of 1636 patients with non\u2010Hodgkin's lymphoma had chemotherapy in Iowa and met inclusion criteria; of these, 316 had at least one hospitalization for neutropenia. The 316 patients had 418 stays. Patients with advanced stage (vs limited stage), previous anemia (vs no anemia), positive Charlson comorbidity score (vs score of 0), and diffuse large cell histology (vs follicular) had higher mean neutropenia\u2010related hospitalization cost\/patient with non\u2010Hodgkin's lymphoma (p&lt;0.05). Among those with neutropenia\u2010related hospitalizations, a longer length of stay was associated with nonfollicular histologies, previous anemia, and positive Charlson score (p&lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    When estimating expected payments for neutropenia\u2010related hospitalization in patients with non\u2010Hodgkin's lymphoma, payers need to be aware of the distribution of clinical characteristics in these patients.\n                  <\/jats:p>","DOI":"10.1592\/phco.25.5.668.63586","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T04:43:46Z","timestamp":1118724226000},"page":"668-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Clinical Characteristics on Neutropenia\u2010Related Inpatient Costs Among Newly Diagnosed Non\u2010Hodgkin's Lymphoma Cases During First\u2010Course Chemotherapy"],"prefix":"10.1002","volume":"25","author":[{"given":"Elizabeth A.","family":"Chrischilles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald G.","family":"Klepser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret D.","family":"Voelker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari S.","family":"Chen\u2010Hardee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane D.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"763","article-title":"Incidence, cost, and mortality of neutropenia hospitalization (NH) associated with chemotherapy [abstr]","volume":"22","author":"Weiss RV","year":"2003","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_3_2","first-page":"27","article-title":"Mortality and economic impact of hospitalization with febrile neutropenia in patients with breast cancer: analysis of a nationwide database [abstr]","volume":"22","author":"Kuderer NM","year":"2003","journal-title":"Proc Am Soc Clin 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Available fromhttp:www.cms.hhs.govprovidershippsippspufs.asp. AccessedJuly 2002."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2001.n.011"},{"key":"e_1_2_1_20_2","first-page":"763","article-title":"Time to first neutropenia hospitalization during chemotherapy for non\u2010Hodgkin's lymphoma: an Iowa SEER\u2010Medicare study [abstr]","volume":"22","author":"Chrischilles EA","year":"2003","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_21_2","unstructured":"VoelkerMD RubensteinLM ChrischillesEA et al.Time to first neutropenia hospitalization during first course chemotherapy among newly diagnosed non\u2010Hodgkin's lymphoma patients: national SEER\u2010Medicare study. Presented at the 45th annual meeting of the American Society of Hematology San Diego CA December 69 2003."},{"key":"e_1_2_1_22_2","unstructured":"BrooksJM VoelkerMD Chen\u2010HardeeSS.Neutropenia\u2010related inpatient Medicare costs during first course chemotherapy among newly diagnosed non\u2010Hodgkin's lymphoma patients: national SEER\u2010Medicare study. Presented at the 45th annual meeting of the American Society of Hematology San Diego CA December 69 2003."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753060-00005"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200203000-00004"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.25.5.668.63586","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.25.5.668.63586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:01:22Z","timestamp":1761069682000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.25.5.668.63586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1592\/phco.25.5.668.63586"],"URL":"https:\/\/doi.org\/10.1592\/phco.25.5.668.63586","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"2012-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}