{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:37:22Z","timestamp":1773419842538,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":2165,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>\n                    <jats:bold>Study Objective<\/jats:bold>\n                    . To determine whether discontinuation of stavudine or protease inhibitor therapy improves human immunodeficiency virus (HIV)\u2013related fat distribution in men.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    . Observational, retrospective study consisting of a cross\u2010sectional (part 1) and a longitudinal (part 2) study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Data Source<\/jats:bold>\n                    . Medical records from Purpan University Hospital and La Grave University Hospital, Toulouse, France.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects<\/jats:bold>\n                    . Eighty men with HIV infection treated with antiretrovirals and 151 healthy male controls matched for age.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Measurements and Main Results<\/jats:bold>\n                    . In part 1, body composition and fat distribution of the HIV\u2010infected men were compared by dual energy x\u2010ray absorptiometry (DEXA) with those of the controls to determine whether body fat distribution is altered in HIV\u2010infected men. In part 2, we analyzed modifications of body composition and fat distribution in 45 of the 80 patients. These 45 had been exposed to antiretroviral drugs, including stavudine and a protease inhibitor, for at least 5 months before the first of two DEXA assessments. They received three different treatment strategies for several months. In group 1, stavudine was withdrawn; in group 2, protease inhibitor was discontinued, and in group 3, stavudine plus protease inhibitor were continued. Group 1 showed a significant fat gain in the lower extremities 31.7 \u00b1 5.9 months after stavudine discontinuation (p&lt;0.0001). Group 2 did not show any significant modification of total body, lower limb, or trunk fat despite protease inhibitor discontinuation for 35.2 \u00b1 6.6 months. Findings were similar for group 3, who continued receiving stavudine\u2010protease inhibitor therapy for 21.2 \u00b1 12.8 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    . These data suggest that long\u2010term withdrawal of stavudine from the antiretroviral therapy regimen may be associated with significant improvement in lipoatrophy in the lower extremities, whereas long\u2010term protease inhibitor withdrawal did not modify fat distribution.\n                  <\/jats:p>","DOI":"10.1592\/phco.26.2.154","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T13:17:10Z","timestamp":1139404630000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Discontinuing Stavudine or Protease Inhibitor Therapy on Human Immunodeficiency Virus\u2014Related Fat Redistribution Evaluated by Dual\u2010Energy X\u2010Ray Absorptiometry"],"prefix":"10.1002","volume":"26","author":[{"given":"Neda","family":"Tavassoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haleh","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Sommet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Delpierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Marion\u2010Latard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Massip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Aquilina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Obadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Labau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean 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of tumor necrosis factor\u2010alpha T\u2010cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus\u2013associated lipodystrophy syndrome","volume":"95","author":"Ledru E.","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000051731.69719.2E"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/339866"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/00002030-199909100-00009","article-title":"A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long\u2010term nucleoside analogue therapy","volume":"13","author":"Saint\u2010Marc 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48 weeks of switching patient therapy from stavudine to abacavir or zidovudine","volume":"38","author":"Cherry CL","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:8:3:287"},{"key":"e_1_2_1_24_2","first-page":"29","article-title":"Randomized, controlled, 48\u2010week study of switching stavudine and\/or protease inhibitors to combivir\/abacavir to prevent or reverse lipoatrophy in HIV\u2010infected patients","volume":"33","author":"John M.","year":"2003","journal-title":"AIDS"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/340312"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200005050-00006"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00042560-200107010-00003","article-title":"Antiretroviral treatment simplification with nevirapine in protease inhibitor\u2013experienced patients with HIV\u2010associated 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