{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:12:17Z","timestamp":1790172737112,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":2137,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>Ziconotide intrathecal infusion was recently approved by the United States Food and Drug Administration for the treatment of intractable severe chronic pain. Patients with neuropathic pain make up a significant population among those who experience chronic pain for which there are less than optimal pharmacotherapeutic options. Published clinical trials provide a global view of ziconotide efficacy and safety. A subset of patients in clinical trials obtained complete pain relief, a remarkable finding given the history of drug treatment for neuropathic pain. To provide more information regarding those who respond to ziconotide therapy we discuss three patients with neuropathic pain who received ziconotide infusion. Two patients with longstanding neuropathic pain, one with complex regional pain syndrome (formerly known as reflex sympathetic dystrophy) of the leg and one with lumbar radiculitis, achieved temporary but complete pain relief from single 5\u2010 and 10\u2010\u03bcg epidural test doses. In the third case, a patient with longstanding bilateral leg and foot neuropathic pain from acquired immunodeficiency syndrome and antiretroviral drug therapy achieved considerable pain relief from a long\u2010term continuous intrathecal infusion. The patients who received a single dose had mild central nervous system adverse effects such as sedation, somnolence, nausea, headache, and lightheadedness. The patient who received the intrathecal infusion experienced mild\u2010to\u2010severe adverse effects depending on the rate of infusion; these effects included sedation, confusion, memory impairment, slurred speech, and double vision. This patient could sense impending adverse effects and made rate adjustments or suspended infusion to avert untoward symptoms. In all three cases, patients achieved considerable pain relief that was long\u2010lasting and persisted well after dose administration or suspension of infusion.<\/jats:p>","DOI":"10.1592\/phco.26.3.395","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T08:49:56Z","timestamp":1141030196000},"page":"395-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Ziconotide Infusion for Severe Chronic Pain: Case Series of Patients with Neuropathic Pain"],"prefix":"10.1002","volume":"26","author":[{"given":"Daniel P.","family":"Wermeling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Prialt (ziconotide intrathecal infusion) product information","author":"Elan Pharmaceuticals, Inc.","year":"2005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90221-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01056-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002252200"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00094-U"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00214-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.8.1084"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200005000-00011"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003253349"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.1.63"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00002508-199709000-00012","article-title":"Use of intrathecal SNX\u2013111, a novel N\u2010type voltage sensitive calcium channel blocker, in the management of intractable brachial plexus avulsion pain","volume":"13","author":"Brose W.G.","year":"1997","journal-title":"Clin J Pain"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1403.2001.00121.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00254-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.1.63"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2001.002003253.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0304-3959(99)00255-9","article-title":"Ziconotide for the treatment of severe spasticity after spinal cord injury","volume":"85","author":"Ridgeway B.","year":"2000","journal-title":"Pain"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(96)00007-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03871.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199709000-00019"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.03.001"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.26.3.395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.26.3.395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:25:41Z","timestamp":1761067541000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.26.3.395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1592\/phco.26.3.395"],"URL":"https:\/\/doi.org\/10.1592\/phco.26.3.395","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"2012-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}