{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:51:17Z","timestamp":1761540677536,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":2106,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>A 56\u2010year\u2010old man with heparin\u2010induced thrombocytopenia with thrombosis syndrome (HITTS) received anticoagulation with recombinant hirudin (lepirudin) for emergency coronary artery bypass graft (CABG) surgery and aortic valve replacement. The patient experienced life\u2010threatening refractory bleeding that was successfully treated with recombinant factor VIIa. He had a history of infective endocarditis that resulted in severe aortic insufficiency, three\u2010vessel coronary artery disease, and acute renal failure requiring hemodialysis. The patient was transferred from another hospital for the emergency surgery, but before his transfer, he developed HITTS secondary to therapeutic heparin for a deep vein thrombosis of the lower extremity. The presence of HITTS, the urgent nature of the case, and the availability of the direct thrombin inhibitor led the surgical team to select lepirudin for anticoagulation to facilitate cardiopulmonary bypass. After separation from cardiopulmonary bypass, the patient was in a coagulopathic state due to the inability to reverse the lepirudin and the slowed elimination of the drug secondary to inadequate renal function. As a result, the patient experienced excessive generalized oozing that was unresponsive to traditional therapies and blood product transfusions. Recombinant factor VIIa 35 \u03bcg\/kg was given as rescue therapy. The bleeding slowed, which allowed placement of chest tubes and closing of the sternum. The patient was transferred to the intensive care unit in stable condition with no evidence of thrombosis in the freshly placed bypass grafts or on the bioprosthetic valve. Recombinant factor VIIa appears to be a suitable option as salvage therapy in patients with refractory bleeding secondary to anticoagulation with a direct thrombin inhibitor during cardiac surgery.<\/jats:p>","DOI":"10.1592\/phco.26.4.576","type":"journal-article","created":{"date-parts":[[2006,3,22]],"date-time":"2006-03-22T08:13:12Z","timestamp":1143015192000},"page":"576-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Recombinant Factor VIIa for Refractory Bleeding After Cardiac Surgery Secondary to Anticoagulation with the Direct Thrombin Inhibitor Lepirudin"],"prefix":"10.1002","volume":"26","author":[{"given":"Jennifer J.","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendell S.","family":"Akers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chand","family":"Ramaiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy D.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(02)00386-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.6.919"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.09.034"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000114072.71353.D5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018648"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-831044"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000068830.54968.A8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(03)00034-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00017.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00062-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200004001-00023"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200108000-00009"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.126927"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04105-X"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119328"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E123"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MAT.0000136516.16726.35"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90310-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D066"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(00)90117-4"},{"key":"e_1_2_1_23_2","first-page":"700","article-title":"Hirudin anticoagulation for CPB","volume":"30","author":"Wajon P","year":"2002","journal-title":"Anaesth Intensive Care"},{"volume-title":"Refludan (lepirudin) package insert","year":"2004","author":"Berlex Laboratories, Inc","key":"e_1_2_1_24_2"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-831046"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.10.021"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.09.061"},{"key":"e_1_2_1_28_2","unstructured":"The Medicines Company.The Medicines Company completes Angiomax\u2010bivalirudin phase III safety trials in cardiac surgery. 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