{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:37:41Z","timestamp":1766486261162,"version":"build-2065373602"},"reference-count":87,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":1831,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>The management of bipolar disorder has seen significant evolution in terms of the number of treatment options now approved for both the acutely manic phase and the maintenance stages of the illness. In addition, new formulations of traditional agents are available for clinicians to use in their treatment approach. One such example is carbamazepine, which has approval by the United States Food and Drug Administration for the treatment of acute and mixed mania in an extended\u2010release formulation that uses a three\u2010bead delivery system. Although the parent compound has been available for decades, its approval for bipolar disorder is recent despite numerous clinical trials that have supported its use in both the acute and maintenance phases of bipolar disorder. Advantages of the new formulation include less fluctuation in plasma concentration and, in general, improved tolerability. However, issues remain with regard to cytochrome P450 drug\u2010related interactions and the need for therapeutic drug monitoring (e.g., drug concentrations, epoxide metabolite concentrations, hematology, and liver function tests) as part of the treatment and monitoring process. We review the current body of literature describing the use of carbamazepine in bipolar disorder during both the acute and maintenance phases of the disorder, including trials of both monotherapy and combination therapy, as well as findings from trials that included patients with rapid cycling and mixed episodes.<\/jats:p>","DOI":"10.1592\/phco.27.1.68","type":"journal-article","created":{"date-parts":[[2006,12,28]],"date-time":"2006-12-28T07:34:50Z","timestamp":1167291290000},"page":"68-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Historical Review of Carbamazepine for the Treatment of Bipolar Disorder"],"prefix":"10.1002","volume":"27","author":[{"given":"Steven C.","family":"Stoner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh Anne","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica W.","family":"Lea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Marken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger W.","family":"Sommi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan M.","family":"Dahmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1257","volume-title":"Pharmacotherapy: a pathophysiologic approach","author":"Fankhauser MP","year":"2005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0111"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950010008002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70334-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0906"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"issue":"4","key":"e_1_2_1_8_2","first-page":"1","article-title":"Practice guideline for the treatment of subjects with bipolar disorder (revision)","volume":"159","author":"American Psychiatric Association","year":"2002","journal-title":"Am J Psychiatry"},{"key":"e_1_2_1_9_2","first-page":"1","article-title":"The expert consensus guideline series: treatment of bipolar disorder 2004","author":"Keck PE","year":"2004","journal-title":"Postgrad Med Special Report"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0404"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.1.3"},{"issue":"5","key":"e_1_2_1_12_2","first-page":"5","article-title":"Mood stabilizers and the evolution of maintenance study designs in bipolar I disorder","volume":"60","author":"Calabrese JR","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X59120"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.463006.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0201"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001518"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1077(200006)15:4<237::AID-HUP160>3.0.CO;2-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026053386962"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038010-00003"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.20.12.139S.35255"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1990.tb01603.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00291.x"},{"volume-title":"Tegretol XR (carbamazepine extended\u2010release tablet) package insert","year":"2003","author":"Novartis Pharmaceuticals.","key":"e_1_2_1_23_2"},{"volume-title":"Equetro (carbamazepine extended\u2010release capsule) package insert","year":"2004","author":"Shire Pharmaceuticals.","key":"e_1_2_1_24_2"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010005"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/js980203"},{"key":"e_1_2_1_27_2","first-page":"169","article-title":"Reanalysis of carbamazepine and carbamazepine\u2010epoxide pharmacokinetics after multiple dosing of extended\u2010release formulations","volume":"5","author":"Konsil J","year":"2002","journal-title":"J Pharm Pharmaceut Sci"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01372.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.2217\/14750708.2.4.533"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.11.1170"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.5.464"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.073114"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200519080-00006"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.047530"},{"key":"e_1_2_1_35_2","first-page":"39","article-title":"2004 Guide to psychiatric drug interactions","volume":"11","author":"Preskorn SH","year":"2004","journal-title":"Prim Psychiatry"},{"volume-title":"Emsam (transdermal selegiline) package insert","year":"2006","author":"Somerset Pharmaceuticals.","key":"e_1_2_1_36_2"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.10.013"},{"key":"e_1_2_1_38_2","first-page":"262","volume":"307","author":"Weiss J","year":"2003","journal-title":"Interaction of antiepileptic drugs with human P-glycoprotein"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.04.011"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163771.96962.1F"},{"issue":"3","key":"e_1_2_1_41_2","first-page":"56","article-title":"The AED (antiepileptic drug) pregnancy registry: a six\u2013year experience [abstr]","volume":"45","author":"Wyszynski DF","year":"2004","journal-title":"Epilepsia"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70224-6"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.776"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.7.1001"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428308"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014497"},{"key":"e_1_2_1_47_2","first-page":"159","article-title":"Therapeutic effects of carbamazepine in affective illness: a preliminary report","volume":"2","author":"Ballenger J","year":"1978","journal-title":"Psychopharmacology"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314982"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000380"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-198907000-00005"},{"key":"e_1_2_1_51_2","first-page":"89","article-title":"Carbamazepine versus lithium in mania: a double\u2010blind study","volume":"48","author":"Lerer B","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145704004651"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.3.378"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00431111"},{"key":"e_1_2_1_55_2","first-page":"490","article-title":"The comparative efficacy and safety of carbamazepine versus lithium: a randomized, double\u2010blind 3\u2010year trial in 83 subjects","volume":"47","author":"Placidi GF","year":"1986","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.2.180"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.153.2.198"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810340047006"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1992.tb01453.x"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n1102"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054844"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0206"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702005251"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(96)01427-9"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199914050-00002"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199914050-00003"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199812000-00007"},{"key":"e_1_2_1_68_2","first-page":"465","article-title":"A lithium and carbamazepine combination in the treatment of bipolar disorder: preliminary report","volume":"35","author":"Inoue K","year":"1981","journal-title":"Folia Psychiatr Neurol Jpn"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb06735.x"},{"key":"e_1_2_1_70_2","first-page":"58","article-title":"The long\u2010term management of bipolar disorders with lithium, carbamazepine, and antidepressants","volume":"46","author":"Fawcett J","year":"1985","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(85)90051-5"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(86)90320-3"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199010000-00003"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(90)90010-P"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1991.tb05575.x"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(92)90054-I"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014301"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.2.208"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199704000-00005"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0204"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2003.00126.x"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.2.179"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1159\/000118969"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199808000-00005"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0403"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0405"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0308"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0511"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.27.1.68","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.27.1.68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:58:51Z","timestamp":1761044331000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.27.1.68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1592\/phco.27.1.68"],"URL":"https:\/\/doi.org\/10.1592\/phco.27.1.68","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2012-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}