{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:16:34Z","timestamp":1773238594077,"version":"3.50.1"},"reference-count":73,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":1497,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>The clinical syndrome of chronic stable angina is an age\u2010related condition that is one common manifestation of coronary artery disease (CAD). The presence of angina significantly affects quality of life when patients must limit their activities of daily living in an effort to prevent the occurrence of anginal attacks. In addition, patients are at risk for significant complications of CAD such as myocardial infarction, heart failure, stroke, and death. Therefore, treatment should focus not only on relief of symptoms and improvements in quality of life, but also on preventing disease progression and reducing the risk of complications from CAD. All patients should be instructed on the appropriate use of sublingual nitroglycerin for the immediate treatment of anginal episodes. \u03b2\u2010Blockers, calcium channel blockers, long\u2010acting nitrate therapy, and ranolazine can prevent anginal symptoms. In addition, aggressive risk factor management, healthy lifestyle changes, antiplatelet agents such as aspirin, and angiotensin\u2010converting enzyme inhibitors all should be used to prevent disease progression and occurrence of myocardial infarction or death. Many patients will be candidates for revascularization of the myocardium with either percutaneous coronary intervention or coronary artery bypass grafting for relief of symptoms as well as improvement in prognosis. Even after revascularization, patients may still require antianginal drug therapy. All patients undergoing revascularization should be guided to make appropriate lifestyle changes and to make concerted efforts to manage risk factors for CAD.<\/jats:p>","DOI":"10.1592\/phco.27.12.1677","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:17:38Z","timestamp":1196155058000},"page":"1677-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Traditional Management of Chronic Stable Angina"],"prefix":"10.1002","volume":"27","author":[{"given":"Toby C.","family":"Trujillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul P.","family":"Dobesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02848-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.179918"},{"key":"e_1_2_1_4_2","volume-title":"Heart disease: a textbook of cardiovascular medicine","author":"Morrow DA","year":"2005"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/jama.1997.03540330037032","article-title":"Five\u2010year clinical and functional outcome comparing bypass surgery and angioplasty in patients with multivessel coronary disease: a multicenter randomized trial","volume":"277","author":"Writing Group for the Bypass Angioplasty Revascularization Investigation (BARI) Investigators.","year":"1997","journal-title":"JAMA"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.11.016"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00436-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061889"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.597500"},{"key":"e_1_2_1_12_2","first-page":"17\u20131","volume-title":"Applied therapeutics: the clinical use of drugs","author":"Trujillo TC","year":"2005"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652859"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00994-X"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.603910"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163635.62927.34"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.061"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042317"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.001"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802193380807"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174516"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.183885"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67528-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072761"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.7.605"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-10-200505170-00011"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.13.1465"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137822.39831.F1"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.842"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.22.2720"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.176158"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92580-1"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.6.779"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11472-3"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.929"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.068"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp040599"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.18.2018"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060989"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.025"},{"key":"e_1_2_1_46_2","unstructured":"SmithSCJr FeldmanTE HirshfeldJWJr et al.ACC\/AHA\/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines (ACC\/AHA\/SCAI writing committee to update the 2001 guidelines for percutaneous coronary intervention). Available fromhttp:www.americanheart.orgpresenter.jhtmlidentifier3035436. Accessed June 1 2007."},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.073"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14286-9"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042739"},{"key":"e_1_2_1_51_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/hrt.2005.078790","article-title":"Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine","volume":"92","author":"Belardinelli L.","year":"2006","journal-title":"Heart"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.08.027"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000184694.03262.6d"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104123441502"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl562"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91033-3"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90518-P"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00491.x"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960150808"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.762"},{"key":"e_1_2_1_61_2","first-page":"S4","article-title":"Stable angina: current state of disease management","volume":"12","author":"Dobesh PP.","year":"2006","journal-title":"J Manag Care Pharm"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00345-Q"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00489-0"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014668"},{"issue":"12","key":"e_1_2_1_65_2","first-page":"301","article-title":"Treatment of stable angina pectoris with calcium antagonists and \u03b2\u2010blockers. The angina prognosis study in Stockholm (APSIS)","volume":"40","author":"Rehnqvist N.","year":"1995","journal-title":"Cardiologia"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.18.2217"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.21.2805"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16980-8"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08265-X"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000185191.86908.a7"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00367-4"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi586"},{"key":"e_1_2_1_73_2","first-page":"1146","article-title":"ACC\/AHA 2004 guidelines update for coronary artery bypass graft surgery\u2014 summary article: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines (committee to update the 1999 guidelines for coronary artery bypass graft surgery)","volume":"44","author":"Eagle KA","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070829"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.27.12.1677","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.27.12.1677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:29:06Z","timestamp":1761046146000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.27.12.1677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":73,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1592\/phco.27.12.1677"],"URL":"https:\/\/doi.org\/10.1592\/phco.27.12.1677","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2012-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}